Azabicycloalkanes as Analgetics. IV. 4-Phenyl-2-azabicyclo [2,2,1] heptanes
スポンサーリンク
概要
- 論文の詳細を見る
As part of studies on the structure-activity relationships of azabicycloalkane antagonistanalgetics, the title compound (II), a five membered alicyclic analog of I (a good mixture of analgetic and antagonist properties), was synthesized. The phenols (XII and XIII) with a bridged 3-phenylpyrrolidine moiety similar to that of I were found to be analgetically inactive. Thus, a shape of the alicyclic ring may also play an important role on the analgetic effectiveness of these derivatives. Interestingly, however, XII and XIII displayed apparent properties of narcotic antagonism on the order of I and pentazocine, the result suggesting that the structural requisite for the antagonist activity in these derivatives, differing from those for analgesia, may be a N-methylphenylethanamine chain.
- 公益社団法人日本薬学会の論文
- 1976-10-25
著者
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武田 幹男
Research Laboratories, Tanabe Seiyaku, Co., Ltd.
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斉藤 清一
田辺製薬研
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斎藤 清一
Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.
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塚本 悟郎
New Drug Research Laboratories Kanebo Ltd.
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塗本 精一
Safety Research Laboratory Tanabe Seiyaku Co. Ltd.
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塗本 精一
Research Laboratories, Tanabe Seiyaku Co., Ltd.
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野口 勝通
Research Laboratories, Tanabe Seiyaku Co., Ltd.
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塚本 悟郎
Research Laboratories, Tanabe Seiyaku Co., Ltd.
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斎藤 清一
Research Laboratories, Tanabe Seiyaku Co., Ltd.
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武田 幹男
Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd.
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野口 勝通
Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd. :(present Address)sapporo Branch Tanab
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