Studies on 1-Alkyl-2 (1H)-pyridone Derivatives. XIII. Syntheses of 5-endo-6-exo-Dicyano- and -Dimethoxycarbonyl-2-methyl-3-oxo-2-azabicyclo [2.2.2] oct-7-ene

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概要

• 論文の詳細を見る

• The Diels-Alder reaction of 1-methyl-2 (1H)-pyridone (I) and fumaronitrile was carried out and the structure of the adduct (II) thereby formed was determined as 5-endo-6-exo-dicyano-2-methyl-3-oxo-2-azabicyclo [2.2.2] oct-7-ene (IIa). IIa was obtained only in a low yield of 3% but the diester compound (Xa) with the same configuration was synthesized in a high yield of 88% by the epimerization of IX, obtained in a quantitative yield from the known VIII.

• 社団法人日本薬学会の論文
• 1970-05-25

著者

• 富澤 宏

  東北薬科大学

• 本郷 弘司

  東北薬科大学

• 富澤 宏

  Tohoku College of Pharmacy

• 藤田 礼子

  Tohoku College of Pharmacy

• 野口 勝通

  Tohoku College of Pharmacy

• 本郷 弘司

  Tohoku College of Pharmacy

• 野口 勝通

  Organic Chemistry Research Laboratory Tanabe Seiyaku Co. Ltd. :(present Address)sapporo Branch Tanab

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