Studies on 1-Alkyl-2 (1H)-pyridone Derivatives. XXIII. The Friedel-Crafts Reaction of 1-Methyl-2 (1H)-pyridone with Aliphatic Acid Derivatives
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The Friedel-Crafts reaction of 1-methyl-2 (1H)-pyridone (I) was examined with three different reagents ; (a) with acid anhydride and sulfuric acid, (b) with acid anhydride and aluminum chloride, and (c) with acid chloride and aluminum chloride. The method (a) afforded the acyl products in a high yield. Products identified as 5-acylated and 3,5-diacylated compounds were obtained by the methods (a) and (b), and 3- and 5-acylated compounds by the method (c).
- 公益社団法人日本薬学会の論文
- 1975-03-25
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