Studies on 1-Alkyl-2 (1H)-pyridone Derivatives. XXVI. A Novel Synthesis of 6-Azabicyclo [3. 2. 1] octane System from 1-Alkyl-2 (1H)-pyridone

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概要

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• The further studies for synthesis of 6-azabicyclo [3. 2. 1] octane derivatives from 1-alkyl-2 (1H)-pyridones (I) are carried out. Reaction of Ia-e with fumaric acid (II) without solvent gave 6-alkyl-7-oxo-6-azabicyclo [3. 2. 1] oct-2-ene-2,8-endo-dicarboxylic acid (IIIa-e) and 6-alkyl-7-oxo-6-azabicyclo [3. 2. 1] oct-2-ene-2,8-exo-dicarboxylic acid (IVa, b, d, e). Reaction of Ia-e with II in water gave IIIa-e. Reaction of Ia with maleic acid in water and without solvent afforded only IIIa.

• 社団法人日本薬学会の論文
• 1979-02-25

著者

• 加藤 秀樹

  Tohoku College Of Pharmacy

• 本郷 弘司

  東北薬科大学

• 藤田 礼子

  Tohoku College of Pharmacy

• 本郷 弘司

  Tohoku College of Pharmacy

• 富沢 宏

  東北薬科大学

• 富沢 宏

  Tohoku College of Pharmacy

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