Studies on 1-Alkyl-2 (1H)-pyridone Derivatives. XXVII. The Diels-Alder Reactions of 1-Methyl-2 (1H)-pyridone with Methyl Acrylate and Acrylonitrile

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概要

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• These studies have been made to get the Diels-Alder adducts having one substituent based on dienophiles. Reaction of 1-methyl-2 (1H)-pyridone (I) with methyl acrylate was carried out. The main product of this reaction followed by hydrolysis was 2-methyl-3-oxo-2-azabicyclo [2. 2. 2] oct-7-ene-6-endo-carboxylic acid (V). When the reaction of I with acrylonitrile was carried out, the products obtained were 7-endo-cyano-2-methyl-3-oxo-2-azabicyclo [2. 2. 2] oct-5-ene (XI), 7-exo-cyano-2-methyl-3-oxo-2-azabicyclo [2. 2. 2] oct-5-ene (XII), and 8-exo-cyano-2-methyl-3-oxo-2-azabicyclo [2. 2. 2] oct-5-ene (XIII).

• 社団法人日本薬学会の論文
• 1979-03-25

著者

• 加藤 秀樹

  Tohoku College Of Pharmacy

• 本郷 弘司

  東北薬科大学

• 藤田 礼子

  Tohoku College of Pharmacy

• 本郷 弘司

  Tohoku College of Pharmacy

• 富沢 宏

  東北薬科大学

• 富沢 宏

  Tohoku College of Pharmacy

• 楢木 孝文

  Tohoku College of Pharmacy

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