2又は4位に脱離基を有するピリジニウム及びキノリニウム四級塩類と活性メチレン化合物との反応
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The reactions of 2- or 4-cyanopyridinium salts with active methylene compounds such as dimethyl malonate, malononitrile, and cyclohexane-1, 3-dione affording 2- or 4-(substituted methylene) pyridines are described. Similar reactions of 4-cyano-2-methylthiopyridinium and 4-cyano-2-methylthioquinolinium salts, both of which have two leaving groups, were readily prepared from 4-cyano-1-methyl-2 (1H)-pyridone and 4-cyano-1-methyl-2 (1H)-quinolone via 4-cyano-1-methyl-2 (1H)-thiopyridone and 4-cyano-1-methyl-2 (1H-thioquinolone in two steps, proceeding at the 2- and/or 4-positions on the pyridine or quinoline rings.
- 社団法人日本薬学会の論文
- 2006-02-01
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