Studies on Prodrugs. II. Preparation and Characterization of (5-Substituted 2-Oxo-1,3-dioxolen-4-yl) methyl Esters of Ampicillin
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概要
- 論文の詳細を見る
(5-Substituted 2-oxo-1,3-dioxolen-4-yl) methyl esters were designed as a new type of ampicillin prodrug. These esters were prepared and confirmed to produce higher blood levels of ampicillin than ampicillin trihydrate itself after oral administration to mice. The compounds which produced particularly high blood levels of ampicillin were found to be hydrolyzed readily in blood in vitro. Ampicillin (5-methyl-2-oxo-1,3-dioxolen-4-yl) methyl ester hydrochloride (KBT-1585) showed the best oral absorbability in mice.
- 公益社団法人日本薬学会の論文
- 1984-06-25
著者
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塚本 悟郎
Pharmaceuticals Research Center, Kanebo Ltd.
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池田 昇司
Pharmaceuticals Reseach Center Kanebo Ltd.
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池田 昇司
Pharmaceuticals Research Center Kanebo Ltd.
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塚本 悟郎
New Drug Research Laboratories Kanebo Ltd.
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坂本 文夫
Pharmaceuticals Reseach Center, Kanebo Ltd.,
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坂本 文夫
Pharmaceuticals Research Center Kanebo Co. Ltd.
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塚本 悟郎
Pharmaceutical Research Laboratory, Tanabe Seiyaku Co., Ltd.
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