Benzylpiperazine Derivatives. III. Quantitative Structure-Cerebral Vasodilating Activity Relationships of 1-Benzyl-4-(3-hydroxy-3-phenylpentyl)piperazine Derivatives(Medicinal Chemistry,Chemical)
スポンサーリンク
概要
- 論文の詳細を見る
Quantitative structure-cerebral vasodilating activity relationships of 1-benzyl-4-(3-hydroxy-3- phenylpropyl)piperazines were examined. The analyses indicate that the potency depends on the number of methoxyl groups on the benzyl moiety, and the local lipophilicity around the asymmetric carbon atom is also of importance. This work reveals that even initial screening data at a single dose can be analyzed quantitatively.
- 公益社団法人日本薬学会の論文
- 1987-07-25
著者
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大高 博
Pharmaceuticals Research Center, Kanebo Ltd.,
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大高 博
New Drug Research Laboratories Kanebo Ltd.
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塚本 悟郎
Pharmaceuticals Research Center, Kanebo Ltd.
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塚本 悟郎
New Drug Research Laboratories Kanebo Ltd.
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塚本 悟郎
Pharmaceutical Research Laboratory, Tanabe Seiyaku Co., Ltd.
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