Novel 4-Phenoxy-2-(1-piperazinyl)quinazolines as Potent Anticonvulsive and Antihypoxic Agents

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概要

• 論文の詳細を見る

• A series of 4-phenoxy-2-(1-piperazinyl)quinazolines was synthesized and examined for anticonvulsive and antihypoxic activities. Many of the compounds exhibited potent anticonvulsive activity comparable to that of carbamazepine or phenytoin. Among them, 4-phenoxy-2-(4-propyl-1-piperazinyl)quinazoline (5w) was selected as the most promising candidate antiepileptic drug with few side effects. It seemed that potent anticonvulsive activity was a prerequisite for potent antihypoxic activity.

• 公益社団法人日本薬学会の論文
• 1990-03-25

著者

• 原 英彰

  鐘紡(株)薬品開発第一研究所薬理研究部

• 原 英彰

  Pharmaceuticals Research Center Kanebo Ltd.

• 洲加本 孝幸

  鐘紡(株)薬品開発第一研究所薬理研究部

• 堀 学

  Pharmaceuticals Research Center, Kanebo Ltd.,

• 家村 隆一

  Pharmaceuticals Research Center, Kanebo Ltd.,

• 尾崎 昭夫

  Pharmaceuticals Research Center, Kanebo Ltd.,

• 洲加本 孝幸

  Pharmaceuticals Research Center, Kanebo Ltd.,

• 大高 博

  Pharmaceuticals Research Center, Kanebo Ltd.,

• 大高 博

  New Drug Research Laboratories Kanebo Ltd.

• 堀 学

  New Drug Research Laboratories, Kanebo Ltd.,

• 尾崎 昭夫

  New Drug Research Laboratories, Kanebo Ltd.,

• 堀 学

  New Drug Research Laboratories Kanebo Ltd.

• 尾崎 昭夫

  New Drug Research Laboratories Kanebo Ltd.

• 家村 隆一

  Pharmaceuticals Research Center Kanebo Ltd.

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