Benzylpiperazine Derivatives. X. : Syntheses ans Structure-Antiulcer Activity Relationship of 1-Benzyl-4-piperazineacetic Acid Esters

スポンサーリンク

概要

• 論文の詳細を見る

• A series of ester derivatives of 1-benzyl-4-piperazineacetic acid was synthesize and evaluated as antiulcer agents. Quantitative structure-activity relationships (QSAR) analyses by using the ALS (adaptive least-squares) method were performed in each step to decrease the synthetic efforts. The QSAR for the esters is much the same as that for the previously examined amide derivatives. The antiulcer activity of these compounds was considered to be based on the cytoprotective activity. The most active and the least toxic compounds, 5n and 5y, were selected for further study.

• 社団法人日本薬学会の論文
• 1988-12-25

著者

• 大高 博

  Pharmaceuticals Research Center, Kanebo Ltd.,

• 大高 博

  New Drug Research Laboratories Kanebo Ltd.

• 吉田 健二

  Pharmaceuticals Research Center Kanebo Ltd.

• 田島 滋

  Pharmaceuticals Research Center Kanebo Ltd.

• 伊藤 敬三

  鐘紡

• 伊藤 敬三

  Pharmaceuticals Research Center Kanebo Ltd.

• 鈴木 健司

  New Drug Research Laboratories Kanebo Ltd.

• 鈴木 健司

  Pharmaceuticals Research Center, Kanebo Ltd.,

• 下原 浩一

  Pharmaceuticals Research Center, Kanebo Ltd.,

• 下原 浩一

  Pharmaceuticals Research Center Kanebo Ltd.

• 伊藤 敬三

  Pharmaceutical Research Center Kanebo Co. Ltd.

関連論文

• Novel 4-Substituted 2-Piperazinylquinazolines as Potent Anticonvulsive and Antihypoxic Agents
• 数種漢方処方の胃機能に対する薬理学的研究-1-エタノ-ルおよびアスピリンによる胃粘膜関門の破綻に対する黄連解毒湯,三黄瀉心湯,安中散および大柴胡湯の作用
• Synthesis and Analgesic Activity of C-Terminal Fragment Peptides of Cholecystokinin(Medicinal Chemistry,Chemical)
• Benzylpiperazine Derivatives. X. : Syntheses ans Structure-Antiulcer Activity Relationship of 1-Benzyl-4-piperazineacetic Acid Esters
• Benzylpiperazine Derivatives. VIII. : Syntheses, Antiulcer and Cytoprotective Activities of 1-(Aminocarbonylalkyl)-4-benzylpiperazine Derivatives and Related Compounds
• 116 1-(2-Ethoxyethyl)-2-(4-methyl-1-homopiperazinyl)benzimidazole difumarate(KB-2413)の抗アレルギー作用(1)I〜IV型アレルギー反応に対する作用
• Studies on Iridoid-Related Compounds. IV. : Antitumor Activity of Iridoid Aglycones
• Design and Syntheses of a Series of Novel Serotonin_3 Antagonists
• Effects of a 2-Substituent on the Ratio of N- and O-Alkylation of 4(3H)-Quinazolinones
• Potential Nootropic Agents, 4-Alkoxy-2-(1-piperazinyl)quinazoline Derivatives
• Novel 4-Phenoxy-2-(1-piperazinyl)quinazolines as Potent Anticonvulsive and Antihypoxic Agents
• Benzylpiperazine Derivatives. XI. : Synthesis of Compounds Related to the Metabolites of 1-[Bis(4-fluorophenyl)methyl]-4-(2,3,4-trimethoxybenzyl)piperazine Dihydrochloride (KB-2796)
• Bioisosteric Transformation of H_1-Antihistaminic Benzimidazole Derivatives
• Quantitative Structure-Activity Relationships of H_1-Antihistaminic Benzimidazole Derivatives
• Syntheses of the Metabolites of 1-(2-Ethoxyethyl)-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-1H-benzimidazole Difumarate (KG-2413) and Related Compounds
• Benzylpiperazine Derivatives. IX. : Structure-Antiulcer Activity Studies of 1-(Aminocarbonylalkyl)-4-benzylpiperazine Derivatives by the Adaptive Least-Squares Method
• Benzylpiperazine Derivatives. VII. Studies on the Role of the Nitrogen Atom in the Cerebral Vasodilating Activity of 1-Benzyl-4-diphenyl-methylpiperazine Derivatives(Medicinal Chemistry,Chemical)
• Benzylpiperazine Derivatives. VI. Design and Syntheses of Vinylogs of 1-Benzyl-4-diphenylmethylpiperazine Derivatives and Their Cerebral Vasodilating Activities(Medicinal Chemistry,Chemical)
• Benzylpiperazine Derivatives. V. Quantitative Structure-Activity Relationships of 1-Benzyl-4-diphenylmethylpiperazine Derivatives for Cerebral Vasodilating Activity(Medicinal Chemistry,Chemical)
• Benzylpiperazine Derivatives. III. Quantitative Structure-Cerebral Vasodilating Activity Relationships of 1-Benzyl-4-(3-hydroxy-3-phenylpentyl)piperazine Derivatives(Medicinal Chemistry,Chemical)
• Benzylpiperazine Derivatives. II. Syntheses and Cerebral Vasodilating Activities of 1-[(3-Alkyl-3-hydroxy-3-phenyl)propyl]-4-benzylpiperazine Derivatives(Medicinal Chemistry,Chemical)
• Benzylpiperazine Derivatives. I. Syntheses and Biological Activities of 1-(2,3,4-Trimethoxybenzyl)piperazine Derivatives(Medicinal Chemistry,Chemical)
• Antibacterial Activity of a New Tetracyclic Quinolone, No, 5290,against Norfloxacin- and Ciprofloxacin-Resistant Strains of Staphylococcus aureus
• Synthesis and Effect on Gastric Secretion of Several Di- or Tripeptides Related to Proglumide
• Synthesis of N-Acyl-γ-D-glutamyl Peptide Derivatives Containing a C-Terminal Small Fragment of Cholecystokinin and Their Effects on Gastric Secretion
• Synthesis and Analgesic Activity of Cholecystokinin-Heptapeptide Analogs with N-Terminal Substitution
• Synthesis of Five Cholecystokinin-like Peptides and Determination of Their Analgesic Effects
• KB-1043ならびに数種抗炎症薬のProstaglandinおよびSRS-A生合成に対する作用
• 新しいベンゾジアゼピン系化合物,7-Chloro-1-cyclopropylmetyl-1,3-dihydro-5-(2-fluorophenyl)-2H-1,4-benzodiazepin-2-one (KB-509)の抗潰瘍作用
• A Novel Ring System, α-Thieno [4,3-f] morphan
• 古典的QSARを活用した新しい骨格構造をもつ虚血性心疾患治療薬の創製 (特集 創薬研究とコンピューター科学(Part2))
• KB-1043ならびに数種抗炎症薬のProstaglandinおよびSRS-A生合成に対する作用
• 新しいベンゾジアゼピン系化合物，7-Chloro-1-cyclopropylmetyl-1，3-dihydro-5-(2-fluorophenyl)-2H-1，4-benzodiazepin-2-one(KB-509)の抗潰瘍作用
• 四塩化炭素および1-Naphtylisothiocyanateによるマウス遅延型皮膚反応の低下に対するCianidanol(KB-53)の作用
• マウス実験的肝障害に対するCianidanol(KB-53)の作用　―病理紅織学的，組織化学的および酵素組織化学的検討―

もっと見る 閉じる

スポンサーリンク