Synthesis of Five Cholecystokinin-like Peptides and Determination of Their Analgesic Effects
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概要
- 論文の詳細を見る
Five CCK (cholecystokinin)-like peptides [CCK(27-32)amide, CCK-6,CCK-7,Boc-CCK-7 and nonsulfated CCK-7] were prepared by stepwise condensation in combination with fragment condensation by the active ester procedure. The analgesic effects of these CCK-like peptides were measured in the writhing test. The ED_<50> value of CCK-7 was 1500 nmol/kg (1.8 mg/kg). Boc-CCK-7 appeared to reduce writhing between doses of 1 and 8 mg/kg but did not show a dose-dependent response. Other synthesic peptides produced no response even at a dose of 8 mg/kg. Our results suggested that CCK-7 is one of the shortest CCK-fragments that can retain the analgesic effect.
- 公益社団法人日本薬学会の論文
- 1986-01-25
著者
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新田 昌宏
Pharmaceuticals Research Center Kanebo Ltd.
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伊藤 敬三
鐘紡
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伊藤 敬三
Pharmaceuticals Research Center Kanebo Ltd.
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井内 浤二
Pharmaceuticals Research Center, Kanebo Ltd.
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森元 康夫
Pharmaceuticals Research Center, Kanebo Ltd.
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塚本 悟郎
Pharmaceuticals Research Center, Kanebo Ltd.
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森元 康夫
Pharmaceuticals Research Center Kanebo Ltd.
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塚本 悟郎
New Drug Research Laboratories Kanebo Ltd.
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井内 浤二
Pharmaceuticals Reseach Center Kanebo Ltd.
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伊藤 敬三
Pharmaceutical Research Center Kanebo Co. Ltd.
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塚本 悟郎
Pharmaceutical Research Laboratory, Tanabe Seiyaku Co., Ltd.
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