Chemical Modification of the Amide Group of Rifamycin S
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概要
- 論文の詳細を見る
Methylation of rifamycin S (1) with MeI in CH_3CN or dimethylformamide (DMF) in the presence of Ag_2O afforded 8-O-methyl-N-methylrifamycin S (3). Demethylation of 3 with MgI_2・ether, followed by treatment with L-ascorbic acid and MnO_2,led to N-methylrifamycin S (4). Rifamycin S imino methylethers 5 and 6 gave the corresponding oxazolorifamycin derivatives 7 and 8 on reduction with L-ascorbic acid.
- 公益社団法人日本薬学会の論文
- 1985-05-25
著者
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塚本 悟郎
Pharmaceuticals Research Center, Kanebo Ltd.
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塚本 悟郎
New Drug Research Laboratories Kanebo Ltd.
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田口 雅裕
Pharmaceuticals Research Center Kanebo Co. Ltd.
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塚本 悟郎
Pharmaceutical Research Laboratory, Tanabe Seiyaku Co., Ltd.
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