Studies on Prodrugs. VI. Preparation and Characterization of (5-Substituted 2-Oxo-1,3-dioxol-4-yl)methyl Esters of Mecillinam(Medicinal Chemistry,Chemical)
スポンサーリンク
概要
- 論文の詳細を見る
As a new type of mecillinam prodrug, raecillinam (5-substituted 2-oxo-1,3-dioxol-4-yl)methyl esters were prepared. These esters were found to produce at least 4-fold higher mecillinam levels in blood than mecillinam itself after oral administration to mice. Mecillinam (5-methyl-2-oxo-1,3-dioxol-4-yl )methyl ester hydrochloride was hygroscopic, but its L-tartrate was not.
- 公益社団法人日本薬学会の論文
- 1987-02-25
著者
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塚本 悟郎
Pharmaceuticals Research Center, Kanebo Ltd.
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池田 昇司
Pharmaceuticals Reseach Center Kanebo Ltd.
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塚本 悟郎
New Drug Research Laboratories Kanebo Ltd.
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平山 良一
Pharmaceuticals Reseach Center Kanebo Ltd.
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坂本 文夫
Pharmaceuticals Reseach Center, Kanebo Ltd.,
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森山 勝
Pharmaceuticals Research Center, Kanebo Co., Ltd.
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外村 幹雄
Pharmaceuticals Research Center, Kanebo Co., Ltd.
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坂本 文夫
Pharmaceuticals Research Center Kanebo Co. Ltd.
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外村 幹夫
Pharmaceuticals Reseach Center Kanebo Ltd.
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外村 幹雄
Pharmaceuticals Research Center Kanebo Co. Ltd.
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森山 勝
Pharmaceuticals Research Center Kanebo Co. Ltd.
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塚本 悟郎
Pharmaceutical Research Laboratory, Tanabe Seiyaku Co., Ltd.
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