OXIDATION OF THIAMINE AIKYLSULFIDE
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概要
- 論文の詳細を見る
Oxidation of S-alkylthiamines and S-alkoxycarbonylthiamines, which are difficult to convert to thiamine by sulfhydryl compounds, was investigated. S-alkylthiamines were oxidized with hydrogen peroxide and perbenzoic acid in glacial acetic acid to afford the corresponding sulfoxides and sulfones in accordance with the amount of the peroxide. α-Acyloxysulfide-type thiamine, which was presumed to be produced via the Pummere's reaction, obtained by the reaction of sulfoxide with acid anhydride.O-Benzoyl-S-ethoxycarbonylthiamine, one of S-alkoxycarbonylthiamines, was oxidized with hydrogen peroxide to give O-benzoylthiaminic acid.
- 日本ビタミン学会の論文
著者
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渡辺 利郎
Pharmaceutical Research Laboratory, Tanabe Seiyaku Co., Ltd.
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塚本 悟郎
Pharmaceutical Research Laboratory, Tanabe Seiyaku Co., Ltd.
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内海 勇
Pharmaceutical Research Laboratory Tanabe Seiyaku Co., Ltd.
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