Synthesis and Analgesic Activity of C-Terminal Fragment Peptides of Cholecystokinin(Medicinal Chemistry,Chemical)
スポンサーリンク
概要
- 論文の詳細を見る
Eleven C-terminal fragment peptides of cholecystokinin (CCK) which contain a O-sulfated tyrosine residue [CCK(27-32), CCK(27-31), CCK(27-31)amide, CCK(27-30), CCK(27-30)amide, CCK(27-29), CCK(27-29)amide, CCK(26-27), CCK(26-27)amide, CCK(25-27) and CCK(25-27)amide] were prepared by the solution method. The syntheses of these peptides were carried out by stepwise condensation in combination with fragment condensation. Analgesic effects of these fragment peptides were measured by means of the writhing test. The ED_<50> value of CCK(27-32) was 9.1mg/kg and that of CCK(25-27) was 7.5mg/kg, but the other synthetic peptides produced no statistically significant response at a dose of 8 or 10mg/kg.
- 社団法人日本薬学会の論文
- 1987-10-25
著者
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田中 隆
長崎大学大学院医歯薬学総合研究科
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新田 昌宏
Pharmaceuticals Research Center Kanebo Ltd.
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伊藤 敬三
鐘紡
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伊藤 敬三
Pharmaceuticals Research Center Kanebo Ltd.
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井内 浤二
Pharmaceuticals Research Center, Kanebo Ltd.
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田中 隆
Pharmaceuticals Research Center, Kanebo Ltd.
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森元 康夫
Pharmaceuticals Research Center, Kanebo Ltd.
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塚本 悟郎
Pharmaceuticals Research Center, Kanebo Ltd.
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森元 康夫
Pharmaceuticals Research Center Kanebo Ltd.
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塚本 悟郎
New Drug Research Laboratories Kanebo Ltd.
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井内 浤二
Pharmaceuticals Reseach Center Kanebo Ltd.
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伊藤 敬三
Pharmaceutical Research Center Kanebo Co. Ltd.
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塚本 悟郎
Pharmaceutical Research Laboratory, Tanabe Seiyaku Co., Ltd.
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