Protective Effects of Morroniside Isolated from Corni Fructus against Renal Damage in Streptozotocin-Induced Diabetic Rats

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概要

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• In our previous study, we reported the renoprotective effect of Hachimi-jio-gan, a Chinese traditional prescription consisting of eight medicinal plants, and also reported the effect of Corni Fructus (Cornus officinalis SIEB. et ZUCC.), a component of Hachimi-jio-gan, on diabetic nephropathy using diabetic rats. In this study, we investigated the effects of morroniside isolated from Corni Fructus on renal damage in streptozotocin-treated diabetic rats. Oral administration of morroniside at a dose of 20 or 100 mg/kg body weight/d for 20 d to diabetic rats resulted in significant decreases in increasing serum glucose and urinary protein levels. Moreover, the decreased levels of serum albumin and total protein in diabetic rats were significantly increased by morroniside administration at a dose of 100 mg/kg body weight/d. In addition, morroniside significantly reduced the elevated serum urea nitrogen level and showed a tendency to reduce creatinine clearance. Morroniside also significantly reduced the enhanced levels of serum glycosylated protein, and serum and renal thiobarbituric acid-reactive substances. Protein expressions related to the advanced glycation endproduct (AGE) level and actions, oxidative stress such as Nε-(carboxyethyl)lysine, as well as receptors for AGE and heme oxygenase-1 were increased in diabetic rats, but the levels were also significantly decreased by the administration of morroniside. This suggests that morroniside exhibits protective effects against diabetic renal damage by inhibiting hyperglycemia and oxidative stress. These results indicate that morroniside is one component partly responsible for the protective effects of Corni Fructus and Hachimi-jio-gan against diabetic renal damage.

• 社団法人日本薬学会の論文
• 2008-07-01

著者

• Yokozawa Takako

  Institute of Natural Medicine, University of Toyama

• 田中 隆

  長崎大学大学院医歯薬学総合研究科

• Tanaka Takashi

  Graduate School Of Education Hiroshima University

• Kang Ki

  Inst. Of Natural Medicine Univ. Of Toyama

• Kang Ki

  富山大学和漢医薬学総合研究所

• Kang Ki

  Institute of Natural Medicine, University of Toyama

• Yamabe Noriko

  Institute of Natural Medicine, University of Toyama

• Yamabe Noriko

  富山大学和漢医薬学総合研究所

• Yamabe Noriko

  Institute Of Natural Medicine University Of Toyama

• Yokozawa Takako

  Inst. Of Natural Medicine Univ. Of Toyama

• Yoshikawa T

  Institute Of Natural Medicine University Of Toyama

• PARK Chan

  Institute of Natural Medicine, University of Toyama

• KIM Hyun

  Institute of Natural Medicine, University of Toyama

• HUR Jong

  Institute of Natural Medicine, University of Toyama

• Kim Hyun

  Dep. Of Food Sci. Jinju National Univ.

• Hur Jong

  Institute Of Natural Medicine University Of Toyama

• Park Chan

  Institute Of Natural Medicine University Of Toyama

• Park Chan

  Institute For Materials Research Tohoku University:(present Address) Jeonbug National University

• Yokozawa Takako

  Institute Of Natural Medicine Toyama Medical And Pharmaceutical University

• Kang Ki

  Institute Of Natural Medicine University Of Toyama

• Tanaka Tomonori

  Faculty Of Medical And Pharmaceutical Sciences Kumamoto University

• 田中 隆

  Faculty Of Pharmaceutical Sciences Kyushu University

• Tanaka T

  School Of Pharmaceutical Sciences Nagasaki University

• Kang Ki

  Univ. Toyama Toyama Jpn

• Kim Hyun

  Institute Of Natural Medicine Toyama Medical And Pharmaceutical University

• Kim Hyun

  Univ. Toyama Toyama Jpn

• 横澤 隆子

  Inst. Of Natural Medicine Univ. Of Toyama

• Kim H

  Univ. Toyama Toyama Jpn

• Tanaka Takemi

  School Of Agriculture Kyushu Tokai University

• Park Chan

  Institute For Laser Engineering Kyung Hee University

• Tanaka Takashi

  Graduate School Of Biomedical Sciences Nagasaki University

• Tanaka Takashi

  Graduate School Of Biochemical Science Nagasaki University

• KIM Hyun

  Institute of Musculoskeletal Aging, Hallym University

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