Protective Effect of Persimmon (Diospyros kaki) Peel Proanthocyanidin against Oxidative Damage under H_2O_2-Induced Cellular Senescence(Pharmacology)
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概要
- 論文の詳細を見る
8-Hydroxy-2'-deoxyguanosine (8-OHdG), one of the most abundant oxidative DNA adducts, is used as an indicator of oxidative DNA damage associated with aging. Among homologs of the silent information regulator (Sir), sirtuin 1 (SIRT1) is suggested as a regulator of the apoptotic response to DNA damage. Since it has been suggested that the aging process can be delayed by the attenuation of oxidative damage such as DNA damage or SIRT1 modulation, we focused on the protective effect against cellular oxidative damage of persimmon peel, a proanthocyanidin-rich food, in relation to its level of polymerization. We confirmed that 8-OHdG expression in TIG-1 human fibroblasts was increased by treatment with 300 μM H_2O_2 for 2 h. On the other hand, the nuclear SIRT1 level was decreased in H_2O_2-treated as compared with non-pretreated cells. However, pretreatments with polymers and oligomers led to a decrease in 8-OHdG and elevation in nuclear SIRT1 expression in a concentration-dependent manner. In particular, oligomers exerted a stronger effect. The present study supports the protective potential of proanthocyanidin from persimmon peel against oxidative damage under the aging process, and suggests that the polymerization of proanthocyanidin plays an important role in retarding aging in a cellular senescence model.
- 社団法人日本薬学会の論文
- 2008-06-01
著者
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Yokozawa Takako
Institute of Natural Medicine, University of Toyama
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CHO Eun
Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine
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Yokozawa Takako
Inst. Of Natural Medicine Univ. Of Toyama
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Yoshikawa T
Institute Of Natural Medicine University Of Toyama
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LEE Young
Institute of Natural Medicine, University of Toyama
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Cho Eun
Department Of Food Science And Nutrition Pusan National University
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Cho E
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Yokozawa Takako
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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CHO Eun
富山医科薬科大学和漢薬研究所
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Lee Young
Institute For Protein Research Osaka University And Crest Japan Science And Technology Cooperation
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Cho Eun
Department Of Dermatology St Vincent Hospital College Of Medicine The Catholic University Of Korea
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Lee Young
Institute Of Natural Medicine University Of Toyama
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横澤 隆子
Inst. Of Natural Medicine Univ. Of Toyama
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Cho Eun
Department Of Chemistry Yeungnam University
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Lee Young
Institute For Geomatics Korean Association Of Surveying & Mapping
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CHO Eun
Department of Animal Science and Biotechnology, Gyeongnam National University of Science and Technology
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