Inhibitory Activities of Proanthocyanidins from Persimmon against Oxidative Stress and Digestive Enzymes Related to Diabetes
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概要
- 論文の詳細を見る
The present study was carried out to evaluate the promising potential of polymers and oligomers from proanthocyanidins of persimmon peel as antioxidants and therapeutic agents for diabetes. Both polymers and oligomers showed the scavenging effect of 2,2-diphenyl-1-picrylhydrazyl, with IC_<50> values of 4.35 and 2.41μg/mL, respectively, and they also showed a protective activity against protein oxidation induced by 2,2'-azobis (2-amidinopropane) dihydrochloride. In particular, oligomers exerted a stronger activity against free radicals than polymers. In addition, to investigate their protective potential against diabetes-related pathological conditions, their inhibitory activities on digestive enzymes and advanced glycation endproduct (AGE) formation were evaluated. Polymers showed a strong inhibitory activity against α-amylase, while oligomers had a relatively weak effect. This suggests that the inhibition of α-amylase activity would probably depend on the degree of polymerization. On the other hand, against α-glucosidase activity and AGE formation, oligomers exerted a stronger protective effect than polymers. The present study suggests that polymers and oligomers from proanthocyanidins of persimmon peel could play a role as antidiabetic agents with antioxidative effects. Moreover, oligomers rather than polymers from proanthocyanidins of persimmon peel may be expected to be a more promising antioxidative and antidiabetic agent in relation to utilization in biological systems.
- 日本ビタミン学会の論文
著者
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Yokozawa Takako
Institute of Natural Medicine, University of Toyama
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Tanaka Takashi
Graduate School Of Education Hiroshima University
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田中 孝幸
Daiichi Seiyaku Co. Ltd.
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CHO Eun
Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine
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Yokozawa Takako
Inst. Of Natural Medicine Univ. Of Toyama
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Yoshikawa T
Institute Of Natural Medicine University Of Toyama
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LEE Young
Institute of Natural Medicine, University of Toyama
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Cho Eun
Department Of Food Science And Nutrition Pusan National University
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Cho E
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Tanaka T
Graduate School Of Biomedical Sciences Nagasaki University
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Yokozawa Takako
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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CHO Eun
富山医科薬科大学和漢薬研究所
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Lee Young
Institute For Protein Research Osaka University And Crest Japan Science And Technology Cooperation
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Cho Eun
Department Of Dermatology St Vincent Hospital College Of Medicine The Catholic University Of Korea
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Lee Young
Institute Of Natural Medicine University Of Toyama
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横澤 隆子
Inst. Of Natural Medicine Univ. Of Toyama
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Tanaka Takemi
School Of Agriculture Kyushu Tokai University
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Cho Eun
Department Of Chemistry Yeungnam University
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Lee Young
Institute For Geomatics Korean Association Of Surveying & Mapping
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Tanaka Takashi
Graduate School Of Biomedical Sciences Nagasaki University
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Tanaka Takashi
Graduate School Of Biochemical Science Nagasaki University
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CHO Eun
Department of Animal Science and Biotechnology, Gyeongnam National University of Science and Technology
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