Confirmation that Luobuma ameliorates the deterioration of antioxidant defense in senescence-accelerated mice
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概要
- 論文の詳細を見る
羅布麻エキスが老化における酸化防御機構にいかなる影響を及ぼしているかについて,老化促進マウス(SAM)を用い検討した。SAMと同じ系統ではあるが,通常の老化過程を辿るAKR/N Slcマウスに比べ,SAMでは肝,腎組織中のグルタチオンレベルとグルタチオン/グルタチオンジスルフィド比は低下し,脂質過酸化物のマロンジアルデヒドは逆に増加していた。一方,羅布麻エキスを投与したSAMでは,これらパラメーターがいずれも改善し,グルタチオン酸化還元サイクルに関係している肝組織中のスーパーオキシドジスムターゼ,グルタチオンペルオキシダーゼ,グルタチオンレダクターゼ活性と腎組織中のスーパーオキシドジスムターゼ活性が有意に上昇していた。また肝組織中のマロンジアルデヒドも低下し,SAMで認められた酸化的ストレス状態を羅布麻エキスが緩和していた。
- 2001-02-28
著者
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Yokozawa Takako
Institute of Natural Medicine, University of Toyama
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HATTORI Masao
Institute of Natural Medicine, University of Toyama
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NAKAGAWA Takako
Department of Kampo Diagnostics, Institute of Natural Medicine, University of Toyama
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横澤 隆子
富山大学和漢医薬学総合研究所
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Yokozawa Takako
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Hattori Masao
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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横澤 隆子
Institute of Natural Medicine
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Chen Cui
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Chen Gui
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Hattori Masao
Institute Of Natural Medicine Faculty Of Pharmaceutical Sciences
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