Triterpenes from the Spores of Ganoderma lucidum and Their Cytotoxicity against Meth-A and LLC Tumor Cells

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概要

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• Six new highly oxygenated lanostane-type triterpenes, called ganoderic acid γ(1), ganoderic acid δ(2), ganoderic acid ε(3), ganoderic acid ζ(4), ganoderic acid η(5) and ganoderic acid θ(6), were isolated from the spores of Ganoderma lucidum, together with known ganolucidic acid D (7) and ganoderic acid C2 (8). Their structures of the new triterpenes were determined as (23S)-7β, 15α, 23-trihydroxy-3,11-dioxolanosta-8,24(E)-diene-26-oic acid (1), (23S)-7α, 15α, 23-trihydroxy-3,11-dioxolanosta-8,24(E)-diene-26-oic acid (2), (23S)-3β, 7β, 23-trihydroxy-11,15-dioxolanosta-8,24(E)-diene-26-oic acid (3), (23S)-3β, 23-dihydroxy-7,11,15-trioxolanosta-8,24(E)-diene-26-oic acid (4), (23S)-3β, 7β, 12β, 23-tetrahydroxy-11,15-dioxolanosta-8,24(E)-diene-26-oic acid (5) and (23S)-3β, 12β, 23-trihydroxy-7,11,15-trioxolanosta-8,24(E)-diene-26-oic acid (6), respectively, by chemical and spectroscopic means, which included the determination of a chiral center in the side chain by a modification of Mosher's method. The cytotoxicity of the compounds isolated from the Ganoderma spores was carried out in vitro against Meth-A and LLC tumor cell lines.

• 社団法人日本薬学会の論文
• 2000-07-01

著者

• Min Byung-sun

  Coll. Of Pharmacy Catholic Univ. Of Daegu

• Min B‐s

  College Of Pharmacy Catholic University Of Daegu

• Min Byung

  Institute Of Natural Medicine Toyama Medical And Pharmaceutical University

• 花岡 美代次

  金沢大学薬学部

• Nakamura Norio

  Institute Of Natural Medicine University Of Toyama

• HATTORI Masao

  Institute of Natural Medicine, University of Toyama

• GAO Jiang-Jing

  Institute of Natural Medicine, University of Toyama

• MIN Byung-Sun

  Institute of Natural Medicine, Toyama Medical and Pharmaceutical University

• Gao Jiang-jing

  Institute Of Natural Medicine Toyama Medical And Pharmaceutical University

• Gao Jiang

  Institute Of Natural Medicine Toyama Medical And Pharmaceutical University

• Gao Jiang

  Institute Of Natural Medicine Facully Of Pharmaceutical Sciences And Pharmaceutical University

• Hattori Masao

  Institute Of Natural Medicine University Of Toyama

• Min Byung

  College Of Pharmacy Catholic University Of Daegu

• Nakamura N

  Institute Of Natural Medicine Toyama Medical And Pharmaceutical University

• Hattori Masao

  Institute Of Natural Medicine Faculty Of Pharmaceutical Sciences

• Hattori Masao

  Metabolic Engineering Institute Of Natural Medicine University Of Toyama

• Nakamura Norio

  Institute Of Natural Medicine Toyama And Pharmaceutical University

• Nakamura Norio

  Institute Of Natural Medicine

• 花岡 美代次

  Institute Of Natural Medicine University Of Toyama

• Min Byoug-Sun

  Institute of Natural Medicine, Toyama Medical and Pharmaceutical University

• Gao Jang-Jing

  Institute of Natural Medicine, Toyama Medical and Pharmaceutical University

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