INVERSION OF A HYDROXYL GROUP BY THE NEIGHBORING-GROUP PARTICIPATION OF A URETHANE : A GENERAL AND STEREOSELECTIVE SYNTHESIS OF (±)-RADDEANONE, (±)-YENHUSOMIDINE, AND RELATED SPIROBENZYLISOQUINOLINE ALKALOIDS

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概要

• 論文の詳細を見る

• (±)-Raddeanone (1) was stereoselectively synthesized from the corresponding protoberberine (5) <via>___- the katal (17) in four steps.Inversion of a hydroxyl group in the katal (17) was realized by the neighboring-group participation of a urethane to afford the diastereoisomeric ketal (22), which was easily converted to (+)-yenhysomidine (3). These alkaloids (1 and 3) were convetred to (±)-reddeanine (18), (±)-reddeanidine (20), and (±)-yenhusomine (25).

• 公益社団法人日本薬学会の論文
• 1988-10-25

著者

• 花岡 美代次

  金沢大学薬学部

• 花岡 美代次

  Faculty Of Pharmaceutical Sciences Osaka University

• 花岡 美代次

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 安田 信吾

  金沢大・薬

• 安田 信吾

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 神津 真澄

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 神津 真澄

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 花岡 美代次

  Institute Of Natural Medicine University Of Toyama

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