Studies on 1-Azabicyclo Compounds. XV. Oxidation of 1,3,4,6,11,11a-Hexahydro-2H-pyrazino [1,2-b] isoquinolin-1-one Derivatives with Mercuric Acetate, and Their Conversion into 1,2,3,4,5,6,7,8-Octahydro-2-methyl-2,5-benzodiazecine and Related Compounds
スポンサーリンク
概要
- 論文の詳細を見る
Oxidation of hexahydro-2H-pyrazino [1,2-b] isoquinolin-1-one (Ia) with mercuric acetate gave the α-aminocarbinol (II), which was characterized as the quaternary ammonium bromide (III). Mercuric acetate oxidation of the diamine (VII), however, afforded the lactam (VIII). Treatment of the methiodides (XIIa, XIIb, and XIIc) with lithium in liquid ammonia yielded the piperazinones (XIIIa, XIIIb, and XIIIc), respectively. On the other hand, reduction of the methiodides (XIIa, XIIb, and XIIc) with sodium amalgam furnished selectively the ten-membered aminolactams (XVIa, XVIb, and XVIc), respectively, in fair yields, which were converted to the corresponding ten-membered diamines (XVIIa, XVIIb, and XVIIc).
- 公益社団法人日本薬学会の論文
- 1973-09-25
著者
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加藤 日出男
北陸製薬株式会社
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越中 栄一
Research and Development Division, Hokuriku Seiyaku Co., Ltd.,
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越中 栄一
Research And Development Division Hokuriku Seiyaku Co. Ltd.
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荒田 義雄
Faculty Of Pharmaceutical Sciences Kanazawa University
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花岡 美代次
金沢大学薬学部
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花岡 美代次
Faculty Of Pharmaceutical Sciences Osaka University
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花岡 美代次
Faculty Of Pharmaceutical Sciences Kanazawa University
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