Quinolone系抗菌剤の研究(第1報)7-(2-Aminoethoxy)-, 7-(2-Aminoethylthio)-及び7-(2-Aminoethylamino)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic Acid及びそれらの誘導体の合成と抗菌活性

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概要

• 論文の詳細を見る

• 7-(2-Aminoethoxy)-, 7-(2-aminoethylthio)-, and 7-(2-aminoethylamino)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acids and their derivatives (11a-f, h, j, k, 12a-f, and 13a-f) were synthesized and their antibacterial activities were tested. Among them, compounds (13a, d) having a primary amino group at the terminal position of alkoxy and alkylthio groups were found to have excellent in vitro and in vivo antibacterial activity comparable to those of ciprofloxacin (5). Structure-activity relationship of these compounds was also stated.

• 社団法人日本薬学会の論文
• 1990-04-25

著者

• 加藤 日出男

  北陸製薬株式会社

• 安田 信吾

  北陸製薬株式会社中央研究所研究開発本部

• 伊藤 安夫

  Research and Development Division, Hokuriku Seiyaku Co., Ltd.,

• 伊藤 安夫

  北陸製薬株式会社研究開発本部

• 吉田 敏彦

  北陸製薬株式会社中央研究所

• 山本 陽一

  北陸製薬株式会社中央研究所

• 八木 典幸

  北陸製薬株式会社中央研究所

• 伊藤 安夫

  Research And Development Division Hokuriku Seiyaku Co. Ltd.

• 加藤 日出男

  北陸製薬株式会社中央研究所

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