新規なPhenoxyalkylamine誘導体(第6報)α-[(Phenoxyethylamino)propyl]-α-phenylacetonitrile誘導体の合成とα-遮断作用

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概要

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• α-[(Phenoxyethylamino) propyl]-α-(4-methoxyphenyl) acetonitrile derivatives possessing methyl, bromo, nitro, amino or various sulfonamide groups at 3-position on ring A and an alkoxy group on ring B were synthesized. Their α-blocking activities were tested. The activity of 5-[1-cyano-4-[[2-(2-ethoxyphenoxy) ethyl] amino]-1-isopropylbutyl]-2-methoxy-benzenesulfonamide (15a) and 5-[1-cyano-4-[[2-(5-fluoro-2-methoxyphenoxy) ethyl] amino]-1-isopropylbutyl]-2-methoxybenzenesulfonamide (15c) was close to that of prazosin, a typical α-blocker. Structure-activity relationship of these derivatives is also stated.

• 社団法人日本薬学会の論文
• 1990-10-25

著者

• 加藤 日出男

  北陸製薬株式会社

• 桜井 俊一郎

  北陸製薬株式会社中央研究所研究開発本部

• 安田 信吾

  北陸製薬株式会社中央研究所研究開発本部

• 伊藤 安夫

  Research and Development Division, Hokuriku Seiyaku Co., Ltd.,

• 伊藤 安夫

  北陸製薬株式会社研究開発本部

• 岡田 文恵

  北陸製薬株式会社中央研究所

• 見谷 一也

  北陸製薬株式会社中央研究所

• 伊藤 安夫

  Research And Development Division Hokuriku Seiyaku Co. Ltd.

• 見谷 一也

  Central Research Laboratory Hokuriku Seiyaku Co. Ltd.

• 加藤 日出男

  北陸製薬株式会社中央研究所

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