TRANSFORMATION OF PROTOBERBERINES INTO SPIROBENZYLISOQUINOLINES. STEREOSELECTIVE CONVERSION OF COPTISINE INTO (±)-OCHROBIRINE

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概要

• 論文の詳細を見る

• Reduction of the 8,14-cycloberbin-13-one (7a), derived from coptisine (6a), with LiAlH (OBu^t)_3 gave stereoselectively the alcohol (8a) which was subsequently treated with ethyl chloroformate to afford the oxazolidinone (10a). Hydrolysis of 10a followed by methylation with methyl iodide provided (±)-ochrobirine (1a).

• 公益社団法人日本薬学会の論文
• 1982-09-25

著者

• 桜井 俊一郎

  北陸製薬株式会社中央研究所研究開発本部

• 向 智里

  金沢大学薬学部

• 向 智里

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 安田 信吾

  金沢大・薬

• 向 智里

  Faculty Of Pharmaceutical Sciences Osaka University

• 安田 信吾

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 大島 武

  Faculty Of Pharmaceutical Sciences

• 櫻井 俊一郎

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 櫻井 俊一郎

  Faculty Of Pharmaceutical Sciences Kanazawa University

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