Chemical Transformation of Protoberberines. III. Convenient Synthesis of 8-Methoxyberberinephenolbetaine by Photooxygenation of Berberine. A Novel Conversion of Berberine into (±)-Ophiocarpine, (±)-Epiophiocarpine, (±)-α-Hydrastine, and (±)-β-Hydrastine
スポンサーリンク
概要
- 論文の詳細を見る
Photooxygenation of berberine (5) in methanol in the presence of sodium methoxide and rose bengal afforded the 8,14-dimethoxy-13-oxoberbine (12), which, on being heated in methanol, readily yielded 8-methoxyberberinephenolbetaine (6), a key intermediate to phthalideisoquinoline alkaloids, (±)-α- and (±)-β-hydrastine (7 and 8). Reduction of 6 with sodium borohydride furnished mostly (±)-ophiocarpine (9) and a little (±)-epiophiocarpine (10).
- 公益社団法人日本薬学会の論文
- 1983-03-25
著者
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荒田 義雄
Faculty Of Pharmaceutical Sciences Kanazawa University
-
向 智里
金沢大学薬学部
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向 智里
Faculty of Pharmaceutical Sciences, Kanazawa University
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向 智里
Faculty Of Pharmaceutical Sciences Osaka University
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