Studies on 1-Azabicyclo Compounds. XVIII. Synthesis of Fourteenmembered Ring Diamine, 1,8-Dimethyl-1,8-diazacyclotetradecane, and Related Compounds from Perhydrodipyrido [1,2-a : 1', 2'-d]-pyrazine via Ten-membered Ring Diamine, 2-Methyl-perhydro-2H-pyrid

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概要

• 論文の詳細を見る

• Oxidation of the anti- and syn-diamine (IX and X) with mercuric acetate gave the enaminolactam (XII). Treatment of the methiodides (XIII, XVIII, and XIX) with lithium in liquid ammonia afforded the ten-membered ring aminolactam (XX) in an excellent yield, which was reduced to the ten-membered ring diamine (XXI). Hofmann degradation of the carbamate (XXIII) derived from XXI provided the fourteen-membered ring aminocarbamate (XXVII) and the oxazolidone (XXVIII), which were converted to the fourteen-membered ring diamine (XXX) and the hydroxydiamine (XXXI), respectively.

• 公益社団法人日本薬学会の論文
• 1974-01-25

著者

• 荒田 義雄

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 花岡 美代次

  金沢大学薬学部

• 花岡 美代次

  Faculty Of Pharmaceutical Sciences Osaka University

• 花岡 美代次

  Faculty Of Pharmaceutical Sciences Kanazawa University

• 中川 美信

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 荒川 良夫

  金沢大学薬学部

• 荒川 良夫

  Faculty of Pharmaceutical Sciences, Kanazawa University

• 中川 美信

  Faculty Of Pharmaceutical Sciences Kanazawa University

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