Chemical Transformation of Protoberberines. XV. : A Novel and Efficient Method for the Introduction of Alkyl Groups on the C-13 Position in the Protoberberine Skeleton
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概要
- 論文の詳細を見る
The Wittig reaction of 8,14-cycloberbin-13-ones (4), derived from the corresponding protoberberine alkaloids (2), with methylenetriphenylphosphorane afforded 13-methylene-8,14-cycloberbines (5). Irradiation of 5 with a 100 W high pressure mercury lamp effected photochemically-induced electrocyclic fission of the aziridine ring to yield 13-methylberberine (1a), dehydrocorydaline (1b), and corysamine (1c) in high yield. Introduction of ethyl and propyl groups on the C-13 position in 2 was also conveniently achieved via photochemical reaction of the corresponding alkylidene derivatives (8 and 9,respectively).
- 社団法人日本薬学会の論文
- 1989-12-25
著者
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花岡 美代次
Faculty of Pharmaceutical Sciences, Kanazawa University
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花岡 美代次
金沢大学薬学部
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花岡 美代次
Faculty Of Pharmaceutical Sciences Osaka University
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花岡 美代次
Faculty Of Pharmaceutical Sciences Kanazawa University
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向 智里
金沢大学薬学部
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向 智里
Faculty of Pharmaceutical Sciences, Kanazawa University
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吉田 修治
Faculty of Pharmaceutical Sciences, Kanazawa University
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向 智里
Faculty Of Pharmaceutical Sciences Osaka University
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吉田 修治
Faculty Of Pharmaceutical Sciences Kanazawa University
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花岡 美代次
Institute Of Natural Medicine University Of Toyama
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