Inhibitory Effects of Constituents from Cynomorium songaricum and Related Triterpene Derivatives on HIV-1 Protease

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概要

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• From CH_2Cl_2 and MeOH extracts of the stems of Cynomorium songaricum RUPR. (Cynomoriaceae), ursolic acid and its hydrogen malonate were isolated as inhibitors of human immunodeficiency virus type 1 (HIV-1) protease, with 50% inhibitory concentrations (IC_<50>) of 8 and 6 μM, respectively. Amongst various synthesized dicarboxylic acid hemiesters of related triterpenes, inhibitory activity tended to increase in the order of oxalyl, malonyl, succinyl and glutaryl hemiesters, for triterpenes such as ursolic acid, oleanolic acid and betulinic acid. The most potent inhibition was observed for the glutaryl hemiesters, with an IC_<50> of 4 μM.From the water extract of the stems of C. songaricum, flavan-3-ol polymers, consisting of epicatechin as their extender flavan units, were also found to be potent inhibitory principles against HIV-1 protease.

• 社団法人日本薬学会の論文
• 1999-02-15

著者

• SHIMOTOHNO Kunitada

  Department of Viral Oncology, Institute for Virus Research, Kyoto University

• 花岡 美代次

  金沢大学薬学部

• Ma Chaomei

  Inst. Of Natural Medicine Univ. Of Toyama

• Hattori Masao

  Institute Of Natural Medicine University Of Toyama

• Hattori Masao

  Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu

• NAKAMURA Norio

  Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University

• MIYASHIRO Hirotsugu

  Institute of Natural Medicine, University of Toyama

• MA Chaomei

  Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmace

• MIYASHIRO Hirotsugu

  Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmace

• Nakamura N

  Institute Of Natural Medicine Toyama Medical And Pharmaceutical University

• Shimotohno Kunitada

  Kyoritsu University Of Pharmacy

• Shimotohno Kunitada

  Laboratory For Human Tumor Viruses Institute For Virus Research Kyoto University

• Shimotohno Kunitada

  Department Of Viral Oncology Institute For Virus Research Kyoto University

• Hattori Masao

  Metabolic Engineering Institute Of Natural Medicine University Of Toyama

• Miyashiro H

  Institute Of Natural Medicine University Of Toyama

• Nakamura Norio

  Research Institute For Wakan-yaku (oriental Medicines) Toyama Medical And Pharmaceutical University

• 花岡 美代次

  Institute Of Natural Medicine University Of Toyama

• HATTORI MASAO

  Research Institute for Wakan-Yaku (Oriental Medicines)

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