Screening of Some Indonesian Medicinal Plants for Inhibitory Effects on HIV-1 Protease

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概要

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• Methanol and water extracts of 30 Indonesian plants were investigated for their inhibitory activity on HIV-1 protease (PR). The PR inhibitory activity was determined by incubating the extracts in a reaction mixture containing PR and substrate His-Lys-Aia-Arg-Val-Leu-(pNO_2- Phe)-Glu-Ala-Nle-Ser-NH_2 at pH 5.0 to perform proteolytic cleavage reaction. The cleaved product was measured by reverse-phase HPLC, using a gradient of acetonitrile/0.1% trifluoroacetic acid as a mobile phase. Of the extracts tested, the methanol extracts of Swietenia mahagoni (bark) and Terminalia belerica (fruit peel) and both methanol and water extracts of Woodfordiafloribunda (flower and leaves) showed a strong PR inhibition, with 1C_<50>≦50μg/ml. Five other samples showed more than 80% inhibition at 0.5 mg/ml.

• 日本生薬学会の論文
• 1992-06-20

著者

• 花岡 美代次

  金沢大学薬学部

• KAKIUCHI Nobuko

  Graduate School of Natural Science and Technology, Kanazawa University

• Nagaoka Takema

  Institute Of Natural Medicine Toyama Medical And Pharmaceutical University

• Hattori Masao

  Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu

• Shimotohno Kunitada

  Kyoritsu University Of Pharmacy

• Shimotohno Kunitada

  Laboratory For Human Tumor Viruses Institute For Virus Research Kyoto University

• Shimotohno Kunitada

  Virology Division National Cancer Center Research Institule

• Kakiuchi N

  Graduate School Of Natural Science And Technology Kanazawa University

• Kakiuchi Nobuko

  Research Institute For Wakan-yaku Toyama Medical And Pharmaceutical University

• Kakiuchi Nobuko

  Graduate School Of Natural Sci. And Technol. Kanazawa Univ.

• 花岡 美代次

  Institute Of Natural Medicine University Of Toyama

• Namba Tsuneo

  Research Institute For Wakan-yaku (oriental Medicine) Toyama Medical And Pharmaceutical University

• KUSUMOTO INES

  Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmace

• SUTARDJO SUPRIYATNA

  Department of Pharmacy, Padjadjaran University

• Kusumoto I

  Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu

• Sutardjo Supriyatna

  Department Of Pharmacy Padjadjaran University

• KAKIUCHI NOBUKO

  Research Institute for Wakan-Yaku (Oriental Medicines)

• HATTORI MASAO

  Research Institute for Wakan-Yaku (Oriental Medicines)

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