Biotransformation of Phorbol by Human Intestinal Bacteria
スポンサーリンク
概要
- 論文の詳細を見る
Anaerobic incubation of phorbol(1)from Croton tiglium with human intestinal bacteria afforded five metabolites: isophorbol(2), deoxyphorbol(3), 4β, 9α, 20-trihydroxy-13, 15-seco-16, 15-tigliatriene-3, 13-dione(4), 4β, 9α, 20-trihydroxy-15, 16, 17-trinor-1, 6-tigliadiene-3, 13-dione(5)and 4β, 9α, 20-trihydroxy-14(13→12)-adbeo-12αH-1, 6-tigliadiene-3, 13-dione(6). All these metabolites(2-6)were identified and characterized by spectroscopic means, including two-dimensional(2D)-NMR. Nine defined strains from the human intestine showed an ability to transform 1 to these metabolites.
- 公益社団法人日本薬学会の論文
- 2002-02-01
著者
-
NAKAMURA Norio
富山医科薬科大学和漢薬研究所
-
花岡 美代次
金沢大学薬学部
-
Nakamura Norio
Institute Of Natural Medicine University Of Toyama
-
HATTORI Masao
Institute of Natural Medicine, University of Toyama
-
Hattori M
Research Institute For Wakan-yaku Toyama Medical And Pharmaceutical University
-
ABDEL-HAFEZ Atef
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
-
Abdel-hafez Atef
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
-
Abdel‐hafez A
Institute Of Natural Medicine Toyama Medical And Pharmaceutical Uniyersity
-
Abdel-hafez Atef
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University:department Of Pharmaceuti
-
Nakamura N
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
-
Hattori Masao
Institute Of Natural Medicine Faculty Of Pharmaceutical Sciences
-
Nakamura Norio
Institute Of Natural Medicine
関連論文
- Characterization of anti-herpes simplex virus type 1 activity of an alkaloid FK 3000 from Stephania cepharantha
- Studies on Antispasmodics. VI. Synthesis of N-Alkyl 6- and 7-Diarylmethyleneindolizidinium Bromides
- Studies on Antispasmodics. V. Synthesis and Anticholinergic Activity of N-Alkyl 1- and 2-Diarylmethylene-indolizidinium Bromides
- 鎮痙剤の研究(第4報)Diarylhydroxymethylquinolizidine Methohalidesの合成と抗アセチルコリン作用
- 鎮痙剤の研究(第3報)2位置換Quinolizidine類の簡便な新合成法とそれらの立体構造について
- 鎮痙剤の研究(第2報)3位置換Quinolizidine類の簡便な新合成法とそれらの立体構造について
- Studies on 1-Azabicyclo Compounds. XXVI. Synthesis of Ten-membered Ring Amines from 9a-Cyanomethyl-, 9a-Ethoxycarbonylmethyl-, and 1-Ethoxycarbonyl-octahydroquinolizine
- Synthesis of (±)-Methyldecamine
- Dacarbazineの光分解によって生成する発痛物質の探索
- Convenient Synthesis of 2,3,9,10-Tetraoxygenated Protoberberine Alkaloids and Their 13-Methyl Alkaloids
- 12-3-B3 ダカルバジン注射剤投与時における血管痛原因物質の探索
- 100(P24) 抗腫瘍性スチリルラクトン化合物の高立体選択的合成(ポスター発表の部)
- (o-トリメチルシリルベンズアルデヒド)クロム錯体を活用する高立体選択的反応の開発
- Erythro-Selective Aldol Reaction of Tricarbonyl(η^6-o-trialkylsilylbenzaldehyde)chromium(0) Complexes with Cyclic Ketene Silyl Acetals
- 18 Protoberberineアルカロイドの新規合成とBenzo[c]phenanthridineアルカロイド(±)-Ambinineの全合成(口頭発表の部)
- Chemical Transformation of Protoberberines. XVII. Biomimetic Introduction of an Oxy Functionality at the C-10 Position in the Benzo[c]phenanthridine Skeleton : Synthesis of 2,3,7,8,10-Pentaoxygenated Benzo[c]phenanthridine Alkaloids, Chelilutine and Sangu
- A FIRST TOTAL SYNTHESIS OF (±)-AMBININE
- Chemical Transformation of Protoberberines. XVI. Regioselective Introduction of an Oxy Functionality at the C_-Position of the Benzo[c]phenanthridine Skeleton : A Convenient Synthesis of Macarpine from Oxychelirubine
- Trimethylsilyl Trifluoromethanesulfonate-Catalyzed Aldol Reaction of Various Aldehydes with Silyl Enol Ethers
- A NOVEL DIASTEREOSELECTIVITY IN THE ALDOL REACTION OF CYCLIC KETENE SILYL ACETALS WITH COBALT-COMPLEXED AND UNCOMPLEXED PROPYNALS
- 学術貢献賞受賞 北 泰行氏の業績
- 故荒田義雄先生を偲んで
- イソキノリンアルカロイドの生合成的合成
- サマリーを重要視(キーワードの使い方)
- 科学研究費の配分について(文部省科学研究費申請と配分の問題点)
- 双環状アミン体から中環状アミン類の合成
- Synthetic Studies on Lythraceae Alkaloids. V. Total Synthesis of (±)-Vertaline
- Synthetic Studies on Lythraceae Alkaloids. IV. Total Synthesis of (±)-Methyldecinine
- Total Synthesis of (±)-Lagerine
- Synthetic Studies on Lythraceae Alkaloids. III. Stereoselective Total Synthesis of (±)-Decaline
- Synthetic Studies on Lythraceae Alkaloids. II. The Mannich Reaction of Isopelletierine with 3-Methoxybenzaldehyde and 3-Hydroxybenzaldehyde
- Studies on 1-Azabicyclo Compounds. XXIV. Synthesis and Stereochemistry of 10-Ethyl-, 10-Vinyl-, and 10-Ethynyl-quinolizidine Methiodides
- Studies on 1-Azabicyclo Compounds. XXII. Stereochemistry of 9a-Substituted Quinolizidine Methiodides
- Metabolism and pharmacokinetics in rats of ganoderiol F, a highly cytotoxic and antitumor triterpene from Ganoderma lucidum
- Pharmacokinetic study of benzoylmesaconine in rats using an enzyme immunoassay system
- Protective Effects of a Neutral Polysaccharide Isolated from the Mycelium of Antrodia cinnamomea on Propionibacterium acnes and Lipopolysaccharide Induced Hepatic Injury in Mice
- Quantitative Determination of Bitter Principles in Specimens of Ganoderma lucidum Using High-Performance Liquid Chromatography and Its Application to the Evaluation of Ganoderma Products
- Chemical Transformation of Protoberberines. XV. : A Novel and Efficient Method for the Introduction of Alkyl Groups on the C-13 Position in the Protoberberine Skeleton
- A NOVEL TOTAL SYNTHESIS OF (±)-CRYPTAUSTOLINE, A DIBENZOPYRROCOLINE ALKALOID
- A NOVEL AND BIOMIMETIC SYNTHESIS OF CHELILUTINE AND SANGUILUTINE
- A TOTAL SYNTHESIS OF (±)-CEPHALOTAXINAMIDE
- 64 ProtoberberineアルカロイドからBenzo [c] phenanthridineアルカロイドの生合成的合成(口頭発表の部)
- 58 ProtoberberineアルカロイドからBenzo[c]phenanthridineアルカロイドの高立体選択的合成
- 33 ProtoberberineからBenzo〔c〕phenanthridine及び3-Arylisoquinolineアルカロイドの合成
- Chemical Transformation of Protoberberines. VIII. A Novel Synthesis of (±)-Fumaricine and a Formal Synthesis of (±)-Alpinigenine
- Chemical Transformation of Protoberberines. VII. Efficient Conversion of Protoberberines into Benzindenoazepines via 8,14-Cycloberbines
- Chemical Transformation of Protoberberines. V. Photochemical Valence Isomerization of Berberinephenolbetaines to 8,14-Cycloberbines, Versatile Aziridine Derivatives for a Novel and Efficient Entry to Spirobenzylisoquinolines and Benzindenoazepines
- Chemical Transformation of Protoberberines. XIII. A Novel and Efficient Synthesis of Antitumor Benzo[c]phenanthridine Alkaloids, Nitidine and Fagaronine(Organic,Chemical)
- Chemical Transformation of Protoberberines. XI. A Novel Synthesis of 2,3,10,11-Tetraoxygenated Protoberberine Alkaloids from Corresponding 2,3,9,10-Tetraoxygenated Protoberberine Alkaloids(Organic,Chemical)
- SYNTHESIS OF FAGARIDINE, A PHENOLIC BENZO [c] PHENANTHRIDINE ALKALOID
- Endothelium-dependent vasodilator effect of tannin extract from Cinnamonomi Cortex on isolated rat aorta
- Two New Triterpenes from the Rhizome of Dryopteris crassirhizoma, and Inhibitory Activities of Its Constituents on Human Immunodeficiency Virus-1 Protease
- Enantioselective Dehydroxylation of Enterodiol and Enterolactone Precursors by Human Intestinal Bacteria(Pharmacognosy)
- Developing of anti-HIV agents from natural resources(Chemical & Pharmacological study)
- A New Enzyme Immunoassay for Aconitine and Its Application to Quantitative Determination of Aconitine Levels in Plasma(Pharmacognosy)
- Sesquiterpenes and Alkaloids from Lindera chunii and Their Inhibitory Activities against HIV-1 Integrase
- Flavanone and Flavonol Glycosides from the Leaves of Thevetia peruviana and Their HIV-1 Reverse Transcriptase and HIV-1 Integrase Inhibitory Activities
- Inhibition of Cytopathic Effect of Human Immunodeficiency Virus Type-1 by Various Phorbol Derivatives
- Inhibitory effects of flavonoids on human immunodeficiency virus type-I integrase
- The Heterocyclic Ring Fission and Dehydroxylation of Catechins and Related Compounds by Eubacterium sp.Strain SDG-2, a Human Intestinal Bacterium
- Triterpenes from the Spores of Ganoderma lucidum and Their Cytotoxicity against Meth-A and LLC Tumor Cells
- Inhibition of Human Immunodeficiency Virus Type 1 Reverse Transcriptase and Ribonuclease H Activites by Constituents of Juglans mandshurica
- Inhibitory Effects of Constituents from Cynomorium songaricum and Related Triterpene Derivatives on HIV-1 Protease
- Triterpenes from the Spores of Ganoderma lucidum and Their Inhibitory Activity against HIV-1 Protease
- Screening of medicinal plant extracts for estrogenic activity in combination with a glycosidase treatment
- Development of an enzyme immunoassay system for mesaconitine and its application to the disposition study on mesaconitine
- Enzyme immunoassay for the quantitative determination of ganoderic acid A from Ganoderma lucidum
- New Lanostane Triterpene Lactones from the Vietnamese Mushroom Ganoderma colossum (FR.) C. F. BAKER
- Estrogenic and Anti-estrogenic Activities of Cassia tora Phenolic Constituents
- Isolation and Characterization of a Human Intestinal Bacterium, Eubacterium sp. ARC-2, Capable of Demethylating Arctigenin, in the Essential Metabolic Process to Enterolactone(Pharmacology)
- Protective effects of an acidic polysaccharide isolated from fruiting bodies of Ganoderma lucidum against murine hepatic injury induced by Propionibacterium acnes and lipopolysaccharide
- Inhibitory effect of Yunnan traditional medicines on hepatitis C viral polymerase
- In vivo antitumor effects of bitter principles from the antlered form of fruiting bodies of Ganoderma lucidum
- Three New Lignans, Longipedunins A-C, from Kadsura longipedunculata and Their Inhibitory Activity against HIV-1 Protease
- Antiviral Activity of the Marine Alga Symphyocladia latiuscula against Herpes Simplex Virus (HSV-1) in Vitro and Its Therapeutic Efficacy against HSV-1 Infection in Mice(Pharmacognosy)
- Two Proteins, Mn^, and Low Molecular Cofactor Are Required for C-Glucosyl-Cleavage of Mangiferin(Biochemistry)
- Isolation of a Human Intestinal Bacterium That Transforms Mangiferin to Norathyriol and Inducibility of the Enzyme That Cleaves a C-Glucosyl Bond(Pharmacognosy)
- Constituents of the seeds of Glycyrrhiza uralensis
- Chemical and Biological Evaluation of Germinated and Mature Antler-shaped Fruiting Bodies of Ganoderma lucidum
- Quantitative determination of maleic and succinic acid derivatives in the mycelium of Antrodia cinnamomea
- Conversion of aconitine lipoaconitine by human intestinal bacteria and their antinociceptive effects in mice
- Transformation of Arctiin to Estrogenic and Antiestrogenic Substances by Human Intestinal Bacteria
- An Improved Synthesis of Butyl 4-[(4-Amino-5-chloro-2-methoxybenzoyl)amino]-1-piperidineacetate (AU-224)
- Synthesis and Gastrointestinal Prokinetic Activity of Novel Benzamide Derivatives with Amphoteric Side Chains
- Anti-herpes simplex virus activities of traditional Chinese medicines, used in Yunnan and Tibetan provinces of China
- New Triterpenoid Saponins from the Roots of Sinocrassula asclepiadea
- INVERSION OF A HYDROXYL GROUP BY THE NEIGHBORING-GROUP PARTICIPATION OF A URETHANE : A GENERAL AND STEREOSELECTIVE SYNTHESIS OF (±)-RADDEANONE, (±)-YENHUSOMIDINE, AND RELATED SPIROBENZYLISOQUINOLINE ALKALOIDS
- A CONVENIENT TRANSFORMATION OF SPIROBENZYLISOQUINOLINES TO DEHYDROPHTHALIDEISOQUINOLINES
- Chemical Transformation of Protoberberines. XII. : A Novel Synthesis of Rhoeadine Alkaloids. : An Alternative Synthesis of a Key Intermediate, Benzindenoazepine, for a Synthesis of (±)-cis-Alpinigenine and (±)-cis-Alpinine from Palmatine(Organic,Chemical)
- A FIRST AND STEREOSELECTIVE SYNTHESIS OF (±)-RADDEANAMINE
- A NOVEL AND HIGHLY STEREOSELECTIVE SYNTHESIS OF (±)-SIBIRICINE
- Chemical Transformation of Protoberberines. VI. Ring D Inversion of Protoberberine Alkaloids. Conversion of Berberine into Non-naturally Occurring 11,12-Oxygenated Protoberberines via Spirobenzylisoquinolines
- 54 8,14-Cycloberbineを経由するProtoberberineアルカロイドからSpirobenzylisoquinoline及びBenzindenoazepineアルカロイドの合成
- New Triterpene Aldehydes, Lucialdehydes A-C, from Ganoderma lucidum and Their Cytotoxicity against Murine and Human Tumor Cells
- 26 Lythraceaeアルカロイドの合成 : (±)-Decaline,(±)-Vertaline,(±)-Desmethyldecaline,(±)-Methyldecinine,(±)-Methyllagerineの全合成
- Inhibitory effect of Tibetan medicinal plants on viral polymerases
- Withanolide Derivatives from the Roots of Withania somnifera and Their Neurite Outgrowth Activities
- Inhibitory Effects of Triterpene-Azidothymidine Conjugates on Proliferation of Human Immunodeficiency Virus Type 1 and Its Protease
- Biotransformation of Phorbol by Human Intestinal Bacteria
- Estrogenic and Antiestrogenic Activities of the Roots of Moghania philippinensis and Their Constituents (Pharmacognosy)