Inhibitory effect of Tibetan medicinal plants on viral polymerases
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概要
- 論文の詳細を見る
民族薬物からの新たな抗ウイルス薬の開発を目指して,我々はチベット伝統薬物76種のHIVの逆転写酵素(RTase)およびHCVのRNA依存RNAポリメラーゼ(RbRp)に対する阻害効果を検討した。これら76種のメタノールエキスのうち28検体が100μg/mlの濃度でRTaseに70%以上の阻害効果を示したが、タンニンの効果を排除するためBSA添加後ら効果があったものはこのうち3検体のみであった。一方,同濃度でRdRpに90%以上阻害効果があり,またタンニンの含有率が10%以下のものは8検体であった。さらにRTaseに対するIC_<50>が5.9μg/mlであった薬物のRhodiola sacraのメタノールエキスの分画を行い8イヒ合物を単離した。そのうちdaucosterolにRTase阻害作用を見い出した。
- 和漢医薬学会の論文
- 2003-12-20
著者
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NAKAMURA Norio
富山医科薬科大学和漢薬研究所
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Nakamura Norio
Institute Of Natural Medicine University Of Toyama
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SHIMOTOHNO Kunitada
Institute for Virus Research, Kyoto University
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HATTORI Masao
Institute of Natural Medicine, University of Toyama
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Komatsu Katsuko
Institute of Natural Medicine, University of Toyama
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Hattori Masao
Department Of Metabolic Engineering Institute Of Natural Medicine Toyama Medical And Pharmaceutical
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SHIMOTOHNO Kumiko
Kyoritsu University of Pharmacy
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Hattori M
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Komatsu K
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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Komatsu Katsuko
Institute Of Natural Medicine University Of Toyama
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KIMURA Takako
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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JYO Michiko
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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垣内 信子
金沢大学薬学部
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Komatsu Katsuko
Institute Of Natural Medical Toyama Medicine And Pharmaceutical University
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Shimotohno Kunitada
Institute For Virus Research Kyoto University
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Nakamura N
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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Komatsu Katsuko
Research Center Of Ethnomedicines Institute Of Natural Medicine Toyama Medical And Pharmaceutical Un
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Jyo Michiko
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Kimura Takako
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Hattori Masao
Institute Of Natural Medicine Faculty Of Pharmaceutical Sciences
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Shimotohno Kumiko
Kyoritsu College Of Pharmacy
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Nakamura Norio
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Nakamura Norio
Institute Of Natural Medicine Toyama And Pharmaceutical University
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Nakamura Norio
Institute Of Natural Medicine Facully Of Pharmaceutical Sciences And Pharmaceutical University
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Nakamura Norio
Institute Of Natural Medicine
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Komatsu K
Univ. Toyama Toyama Jpn
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