Estrogenic and Antiestrogenic Activities of the Roots of Moghania philippinensis and Their Constituents (Pharmacognosy)
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概要
- 論文の詳細を見る
In the course of our search for natural estrogenic compounds from medicinal plants, we found that the methanolic extract from the roots of Moghania philippinensis (Fabaceae) showed significant effects on the proliferation of MCF-7 cells (human breast cancer) and induction of β-galactosidase activity in a yeast two-hybrid assay. Through estrogenic activity-guided fractionation, we isolated several active flavonoids including prenylated ones. The CHC1_3 fraction and its new constituent, 8-(l,l-dimethylallyl)genistein (9), appreciably increased the uterine weight in ovariectomized rats when administered orally for 14 consecutive days, in which compound 9 showed stronger estrogenic activity than genistein. Antiestrogenic activities were also examined based on the inhibition of MCF-7 cell proliferation and β-galactosidase activity in the yeast two-hybrid assay, mediated by 17β-estradiol. 5, 7, 3', 4'-Tetrahydroxy-6,8-diprenylisoflavone (6) showed the strongest antiestrogenic activity.
- 公益社団法人日本薬学会の論文
- 2004-04-01
著者
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NAKAMURA Norio
富山医科薬科大学和漢薬研究所
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Nakamura N
Institute Of Natural Medicine University Of Toyama
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Nakamura Norio
Institute Of Natural Medicine University Of Toyama
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HATTORI Masao
Institute of Natural Medicine, University of Toyama
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AKAO Teruaki
Faculty of Pharmaceutical Sciences, University of Toyama
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Nakamura N
Faculty Of Pharmaceutical Sciences Doshisha Women's College Of Liberal Arts
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Akao Teruaki
Faculty Of Pharmaceutical Sciences University Of Toyama
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Akao Teruaki
Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceutical University
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Akao Teruaki
Graduate School Of Medicine And Pharmaceutical Sciences Univ. Of Toyama
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Akao Teruaki
Department Of Enzymatic Physiology Faculty Of Pharmaceutical Sciences Toyama Medical And Pharmaceuti
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Hattori Masao
Department Of Metabolic Engineering Institute Of Natural Medicine Toyama Medical And Pharmaceutical
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NISHIHARA Tsutomu
Laboratory of Environmental Biochemistry, Graduate School of Pharmaceutical Sciences Osaka Universit
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AHN Eun-Mi
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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Ahn E‐m
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Ahn Eun-mi
Institute Of Natural Medicine Toyama Medical And Pharmaceutical Universuty
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Nakamura N
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Nishinaka T
Osaka Univ. Pharmaceutical Sci. Osaka Jpn
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Nishihara T
Department Of Oral Microbiology Kyushu Dental College
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Hattori Masao
Institute Of Natural Medicine Faculty Of Pharmaceutical Sciences
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Nishihara Tsutomu
Laboratory Of Environmental Biochemistry Graduate School Of Pharmaceutical Sciences Osaka University
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Nishihara Tsutomu
Laboratory Of Environmental Biochemistry Graduate School Of Pharmaceutical Sciences Osaka University
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Akao Teruaki
Institute Of Natural Medicine Toyama Medical
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Nishihara T
Fac. Of Pharmaceutical Sciences Hyogo Univ. Of Health Sciences
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Nakamura Norio
Institute Of Natural Medicine Toyama And Pharmaceutical University
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Nakamura Norio
Institute Of Natural Medicine
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Nishihata Tomohiro
Institute Of Natural Medicine University Of Toyama
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