12-O-Acetylphorbol-13-decanoate Potently Inhibits Cytopathic Effects of Human Immunodeficiency Virus Type 1 (HIV-1), without Activation of Protein Kinase C
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概要
- 論文の詳細を見る
Through bioactivity-guided fractionation, eight phorobol di-esters, including five new ones (1-5), were isolated from the seeds of Croton tiglium collected in Egypt. 12-O-Acetylphorbol-13-decanoate (6) and 12-O-decanoylphorobol-13-(2-methylbutyrate) (4) potently inhibited the HIV-1-induced cytopathic effect on MT-4 cells (IC_<100> values of 7.6 ng/ml and 7.81 μg/ml, and CC_0 values of 62.5μg/ml and 31.3 μg/ml, respectively) without activating protein kinase C.
- 社団法人日本薬学会の論文
- 1999-09-15
著者
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MESELHY Meselhy
Institute of Natural Medicine, Faculty of Pharmaceutical Sciences and Pharmaceutical University
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Nakamura Norio
Institute Of Natural Medicine University Of Toyama
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HATTORI Masao
Institute of Natural Medicine, University of Toyama
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Nakamura N
Faculty Of Pharmaceutical Sciences Doshisha Women's College Of Liberal Arts
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Otake Toru
Osaka Prefectural Institute Of Public Health
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Otake Toru
Showa Denko K.k.
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Hattori M
Research Institute For Wakan-yaku Toyama Medical And Pharmaceutical University
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EL-MEKKAWY Sahar
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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KAWAHATA Takuya
Osaka Prefectural Institute of Public Health
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Nakamura N
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Meselhy M
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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Meselhy Meselhy
Faculty Of Pharmacy Cairo University
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Meselhy Meselhy
(present Address)faculty Of Pharmacy Cairo University
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Ohi Tetsuo
Botanical Gardens Graduate School Of Sciences The University Of Tokyo
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Meselhy Meselhy
Institute Of Natural Medicine Faculty Of Pharmaceutical Sciences And Pharmaceutical University
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Kawahata T
Division Of Virology Department Of Infectious Diseases Osaka Prefectural Institute Of Public Health
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Hattori Masao
Institute Of Natural Medicine Faculty Of Pharmaceutical Sciences
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Nakamura Norio
Institute Of Natural Medicine Toyama And Pharmaceutical University
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Nakamura Norio
Institute Of Natural Medicine
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