Biotransformation of (-)-Epicatechin 3-O-Gallate by Human Intestinal Bacteria
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概要
- 論文の詳細を見る
The biotransformation of (-)-epicatechin 3-O-gallate (1) and related compounds was undertaken using a human fecal suspension. Of fifteen metabolites isolated, four compounds were new, namely, two epimers of 1-(3'-hydroxyphenyl)-3-(2", 4", 6"-trihydroxyphenyl)propan-2-ols (6,19); 2", 3"-dihydroxyphenoxyl 3-(3', 4'-dihydroxyphenyl)propionate (14) and 1-(3', 4'-dihydroxyphenyl)-2-(2", 4", 6"-trihydroxyphenyl)propan-2-ol (18).(-)-Epicatechin (2), (-)-epigallocatechin (16) and their 3-O-gallates (1,17) were extensively metabolized by a human fecal suspension after incubation for 24h, whereas the gallates (1,17) resisted any degradation by a rat fecal suspension, even after a prolonged incubation time (48h), suggesting a difference in metabolic ability between two intestinal bacterial mixtures from different species.
- 社団法人日本薬学会の論文
- 1997-05-15
著者
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MESELHY Meselhy
Research Center for Ethnomedicines, Institute of Natural Medicine, Toyama Medical and Pharmaceutical
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Nakamura N
Faculty Of Pharmaceutical Sciences Doshisha Women's College Of Liberal Arts
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Hattori Masao
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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NAKAMURA Norio
Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University
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Nakamura N
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Meselhy M
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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Meselhy Meselhy
Faculty Of Pharmacy Cairo University
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Meselhy Meselhy
(present Address)faculty Of Pharmacy Cairo University
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Meselhy Meselhy
Research Center For Ethnomedicines Institute Of Natural Medicine Toyama Medical And Pharmaceutical U
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Nakamura Norio
Research Institute For Wakan-yaku (oriental Medicines) Toyama Medical And Pharmaceutical University
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HATTORI MASAO
Research Institute for Wakan-Yaku (Oriental Medicines)
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