Studies on Dental Caries Prevention by Traditional Medicines (Part VII) : Screening of Ayurvedic Medicines for Anti-plaque Action

概要

論文の詳細を見る
In the course of basic studies on the dental caries prevention by traditional medicines, various crude drugs used in Sri Lanka were screened for anti-plaque action against Streptococcus mutans. Among these, both of the methanolic and 50% methanolic extracts of "Welmii" (the roots of Glycyrrhiza glabrd) and "Kaluduru" (the seeds of Nigella stativa), and the methanolic extracts of "Wasawasi" (the aril of Myristica fragrans), "Satakuppa" (the seeds of Peucedanum graveolens), "Wal-bevila" (the root of Sida cordifolia) and "Walagasal" (the fruit of Embelia ribes) potently inhibited the adherence of viable cells of S. mutans to smooth surfaces with IC_<50> of 10-30 μg/ml. The methanolic extracts of "Welmii" and "Walagasal" had both antibacterial action against S. mutans and anti-enzymic action against glucosyltransferase. Though active principles of the former extract are not yet clear, that of the latter extract was identified as embelin, which inhibited the bacterial growth with MIC of 62.5 μg/ml and the glucan synthesis with IC_<50> of 125 μg/ml.
日本生薬学会の論文
1985-06-20