Effects of Paeoniflorin Derivatives on Scopolamine-Induced Amnesia Using a Passive Avoidance Task in Mice; Structure-Activity Relationship
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概要
- 論文の詳細を見る
Paeoniflorin (1) and its derivatives having in common a cage-like pinane skeleton with hemiketal-acetal system, were evaluated for their effects on memory impairment induced by scopolamine in mice using a step-down type passive avoidance task. In the test session, 1 and its derivatives were intraperitoneally (i.p.) administered at doses of 0.002,0.01,0.02 and 0.2 mmol/kg, and 30 min later (15 min before the experiment), scopolamine (1 mg/kg, i.p.) was given. These compounds showed dose-dependent attenuation in a dose range of 0.002-0.02 mmol/kg and also enhancement of scopolamine-induced decrease in step-down latency. The effects of these compounds, except that of 2', 3', 4', 5'-O-tetraacetyl-3-O-methylpaeoniflorin (8), followed a bell-shaped dose response profile. 8-Debenzoyl-6-deglucosyl-3-O-methylpaeoniflorin (6) showed no significant increase in the step-down latency at all tested doses. Maximum step-down latency was obtained by 3-O-methylpaeniflorin (3) and 2', 3,3'4', 5'-penta-O-methylpaeoniflorin (7) (the minimal effective dose was 0.002 mmol/kg). Relative to 3,debenzoylation, as in 8-debenzyl-3-O-methylpaeoniflorin (4), slightly increased the latency, while deglucosylation, as in 6-deglucosyl-3-O-methylpaeoniflorin (5), significantly reduced the prolongation of latency. Removal of both glucose and benzoyl moieties resulted in the loss of activity as seen in 6. These results revealed that, in addition to the cage-like pinane skeleton, the benzoyl and the glucosyl moieties are important structural elements of the paeoniflorin skeleton as its effects on scopolamine-induced amnesia.
- 社団法人日本薬学会の論文
- 1998-11-15
著者
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Murakami Yukihisa
富山大学和漢医薬学総合研究所 複合薬物薬理学
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Mukarami Yukihisa
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Murakami Yukihisa
Division Of Medicinal Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical U
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Murakami Yukihisa
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines)
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MESELHY Meselhy
Research Center for Ethnomedicines, Institute of Natural Medicine, Toyama Medical and Pharmaceutical
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Nakamura N
Faculty Of Pharmaceutical Sciences Doshisha Women's College Of Liberal Arts
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WATANABE Hiroshi
Research Group for Biotechnology Development, Japan Atomic Energy Research Institute (JAERI-Takasaki
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Hattori Masao
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines) Toyama Medical And Pharmaceu
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NAKAMURA Norio
Research Institute for Wakan-Yaku, Toyama Medical and Pharmaceutical University
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ABDEL-HAFEZ Atef
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University
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Mohamed Tarek
Department Of Pharmaceutical Medical Chemistry Faculty Of Pharmacy Assiut University
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Mohamed Tarek
Department Of Medicine Caritas St. Elizabeth's Medical Center Tufts University School Of Medici
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EL-GENDY Mahmound
Department of Pharmaceutical Medical Chemistry, Faculty of Pharmacy, Assiut University
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MAHFOUZ Nadia
Department of Pharmaceutical Medical Chemistry, Faculty of Pharmacy, Assiut University
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ABDEL-HAFEZ Atef
Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmace
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MUKARAMI Yukihisa
Research Institute for Wakan-Yaku (Traditional Sino-Japanese Medicines), Toyama Medical and Pharmace
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EL-GENDY Mahmoud
Department of Pharmaceutical Medicinal Chemistry, Faculty of Pharmacy, Assiut University
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Abdel-hafez Atef
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Nakamura N
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Meselhy M
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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Meselhy Meselhy
Faculty Of Pharmacy Cairo University
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Meselhy Meselhy
(present Address)faculty Of Pharmacy Cairo University
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Meselhy Meselhy
Research Center For Ethnomedicines Institute Of Natural Medicine Toyama Medical And Pharmaceutical U
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El-gendy Mahmound
Department Of Pharmaceutical Medical Chemistry Faculty Of Pharmacy Assiut University
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Watanabe H
Toyama Medical And Pharmaceutical Univ. Toyama Jpn
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Murakami Y
Department Of Bioactive Molecules National Institute Of Infectious Diseases
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Mahfouz Nadia
Department Of Pharmaceutical Medical Chemistry Faculty Of Pharmacy Assiut University
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Nakamura Norio
Research Institute For Wakan-yaku (oriental Medicines) Toyama Medical And Pharmaceutical University
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HATTORI MASAO
Research Institute for Wakan-Yaku (Oriental Medicines)
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MAHFOUZ Nadia
Department of Fish Diseases, Faculty of Veterinary Medicine, Kafr El-Sheikh University
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