Paeoniflorin ameliorates acquisition impairment of a simple operant discrimination performance caused by unilateral nucleus basalis magnocellularis lesion in rats
スポンサーリンク
概要
- 論文の詳細を見る
rights: 本文データは和漢医薬学会の許諾に基づき複製したものであるThe effect of paeoniflorin on learning impairment of operant brightness discrimination performance was investigated in rats with unilateral nucleus basalis magnocellularis（NBM）lesion. The animals with unilateral NBM lesion exhibited a significant acquisition impairment of brightness discrimination task during the early phase of a training period（1-5days after starting the training session). When administered daily during a training period，paeoniflorin significantly improved the learning impairment of unilateral NBM-lesioned rats at 0.01 but not 0.1mg／kg／day（p.o.）. Tacrine （0.3mg／kg／day，p.o.）， a cholinesterase inhibitor，also significantly ameliorated the learning deficit. These results suggest that paeoniflorin improves the impairment of non-spatial learning performance caused by cholinergic dysfunction in rats and that it may have a beneficial effect on senile dementia.
- 和漢医薬学会の論文
- 1997-01-01
著者
-
渡辺 裕司
International Research Center For Traditional Medicine Toyama Prefecture International Health Comple
-
Murakami Yukihisa
富山大学和漢医薬学総合研究所 複合薬物薬理学
-
Mukarami Yukihisa
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
-
Murakami Yukihisa
Division Of Medicinal Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical U
-
Murakami Yukihisa
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines)
-
WATANABE Hiroshi
富山医科薬科大学和漢薬研究所生物試験部門
-
Matsumoto Kinzo
Div. Of Medicinal Pharmacology Inst. Of Natural Medicine Univ. Of Toyama
-
Murakami Yukihisa
富山医科薬科大学和漢薬研究所生物試験
-
Matsumoto Kinzo
富山医科薬科大学和漢薬研究所生物試験
-
Maruno Masao
Central Research Laboratories, Tsumura & Co.
-
ICHIKI Hiroyuki
Pharmacognosy and Medicinal Resources Research Department, Tsumura and Co.
-
Matsumoto Kinzo
富山大学和漢医薬学総合研究所 複合薬物薬理学
-
Murakami Y
Department Of Bioactive Molecules National Institute Of Infectious Diseases
-
Maruno Masao
Central Research Laboratories Tsumura & Co.
-
Maruno Masao
Central Research Laboratory Kampo And Pharmacognosy Laboratory Tsumura & Co.
-
Shimizu Mineo
Laboratory Of Pharmacognosy Department Of Medicinal Resources Faculty Of Pharmaceutical Sciences Toy
-
Ichiki Hiroyuki
Central Research Laboratory Kampo And Pharmacognosy Laboratory Tsumura & Co.
-
AKAZAWA Ko-hei
富山医科薬科大学和漢薬研究所
関連論文
- Enhanced expression of BCL2/adenovirus EIB 19-kDa-interacting protein 3 mRNA, a candidate for intrinsic depression-related factor, and effects of imipramine in the frontal cortex of stressed mice
- P-35 一過性脳虚血誘発のマウス学習障害に対する釣藤鈎の作用
- MS-I-3 一過性脳虚血誘発のマウス学習障害に対する釣藤鈎の作用
- Effects of Manganese Complexes of Curcumin and Diacetylcurcumin on Kainic Acid-Induced Neurotoxic Responses in the Rat Hippocampus(Pharmacology)
- Hypouricemic Effects of Acacetin and 4,5-O-Dicaffeoylquinic Acid Methyl Ester on Serum Uric Acid Levels in Potassium Oxonate-Pretreated Rats(Pharmacology)
- Effects of Choto-san and Chotoko on thiopental-induced sleeping time
- 一過性虚血及び抗コリン薬スコポラミン誘発の学習障害に対する四物湯の改善作用及び処方解析
- スコポラミン誘発のマウス学習行動障害に対する四物湯及び構成生薬の影響 : 産婦・中枢神経系
- 生薬資源の生産と品質管理
- Fischer Indolization and Its Related Compounds. XIX. Syntheses of Ethyl 4-Methoxy- and Ethyl 5-Methoxy-1-phenyl-3H-benz [e] indole-2-carboxylates
- Panax ginseng Extract Improves the Scopolamine-Induced Disruption of 8-Arm Radial Maze Performance in Rats
- Panax ginseng Extract Improves the Performance of Aged Fischer 344 Rats in Radial Maze Task but Not in Operant Brightness Discrimination Task
- D-1 老齢ラットの学習行動障害に対する薬用人参の作用
- Corymine Potentiates NMDA-Induced Currents in Xenopus Oocytes Expressing NR1a/NR2B Glutamate Receptors
- P-01 補中益気湯長期間処置によるNG108-15細胞の遺伝子発現変化(脳神経・精神,一般演題ポスター,第24回和漢医薬学会大会 和漢薬の複雑さ-経験知と科学知-)
- The mRNA Expression Differences of RNA Editing Enzymes in Differentiated and Undifferentiated NG108-15 Cells
- Effects of Choto-san and Its Related Constituents on Endogenous Antioxidant Systems(Pharmacology)
- Antioxidant and Free Radical-Scavenging Activity of Choto-san and Its Related Constituents(Pharmacology)
- Chronic Treatment With Imipramine Inhibits Cell Growth and Enhances Serotonin 2C Receptor mRNA Expression in NG 108-15 Cells
- Fischer Indolization of Variously ortho-Substituted Phenylhydrazones (Fischer Indolization and Its Related Compounds. XXV)
- A NEW SYNTHESIS OF EUPOLAURAMINE FROM A BENZ [f] INDOLE DERIVATIVE
- Radiation response mechanisms of the extremely radioresistant bacterium Deinococcus radiodurans
- 脳血管性認知症病態モデルにおける漢方薬「釣藤散」の薬理作用とその機序
- 複合薬物薬理学分野(病態制御部門,各部門・附属センターの活動と業績)
- 複合薬物薬理学分野(病態制御部門,各部門・附属センターの活動と業績)
- 生物試験分野(各部門・附属センターの活動と業績)
- 自然発症高血圧ラットにおける釣藤散の抗高血圧作用 : 釣藤鈎及び石膏の役割について
- P-29 釣藤鈎フェノール分画及び成分の降圧, 脳虚血予防作用
- 生物試験部門
- 釣藤散,釣藤鈎及びそのアルカロイド成分の脳虚血予防作用 : マウス水迷路学習行動を指標として
- P-6 自然発症高血圧ラットの血圧に対する釣藤鈎メタノールエキスおよびそのフェノール成分の作用
- P-5 自然発症高血圧ラットにおける釣藤散の降圧作用
- P-13 両側総頸動脈永久結紮ラットの学習行動に対する薬用人参及びタクリンの影響
- [総合ディスカッション] (現代社会のストレスと漢方の役割)
- 現代社会のストレスと漢方の役割
- 漢方薬の効果発現と臨床応用
- Inhibitory Effects of Corymine-Related Compounds on Glycine Receptors Expressed in Xenopus Oocytes
- タイ薬用植物成分 mitragynine の抗侵害受容作用に関与するオピオイド受容体サブタイプ
- Effects of Mitragynine on cAMP Formation Mediated by δ-Opiate Receptors in NG108-15 Cells
- Behavioral Studies on Alkaloids Extracted from the Leaves of Hunteria zeylanica
- Inhibitory Effect of Alkaloids Extracted from the Stem Bark of Hunteria zeylanica on 5-Lipoxygenase Activity in Vitro
- Effects of Alkaloids Extracted from the Stem Bark of Hunteria zeylanica on Acute Inflammation in Experimental Animals
- Anticonvulsant Activity of Paeonimetabolin-I Adducts Obtained by Incubation of Paeoniflorin and Thiol Compounds with Lactobacillus brevis
- Effects of Paeoniflorin Derivatives on Scopolamine-Induced Amnesia Using a Passive Avoidance Task in Mice; Structure-Activity Relationship
- Synthetic Studies of Indoles and Related Compounds. XXVII. A New Synthesis of Crenatine from Ethyl Indole-2-carboxylate
- Fischer Indolization and Its Related Compounds. XVIII. Formation of Four Unexpected Angular Benz [e] indoles on Fischer Indolization of Ethyl Phenylpyruvate 2-[(1,4-Dimethoxy-2-naphthyl) hydrazone]
- Heavy-Ion Microbeam System at JAEA-Takasaki for Microbeam Biology
- II-B-6 前脳基底核破壊ラットの明暗弁別学習障害に対する paeoniflorin の作用
- Permanent Occlusion of Bilateral Internal Carotid Arteries Produces Cognitive Deficits in Two Learning Behavior Tasks
- Tetramethylpyrazine Improves Spatial Cognitive Impairment Induced by Permanent Occlusion of Bilateral Common Carotid Arteries or Scopolamine in Rats
- Chotosan Enhances Macrophage Colony-Stimulating Factor mRNA Expression in the Ischemic Rat Brain and C6Bu-1 Glioma Cells(Biochemistry)
- Chotosan, a Kampo Formula, Ameliorates Chronic Cerebral Hypoperfusion-Induced Deficits in Object Recognition Behaviors and Central Cholinergic Systems in Mice
- Preventive Effect of Chotosan, a Kampo Medicine, on Transient Ischemia-Induced Learning Deficit Is Mediated by Stimulation of Muscarinic M_1 But Not Nicotinic Receptor(Pharmacology)
- Social Isolation Stress-Induced Oxidative Damage in Mouse Brain and Its Modulation by Majonoside-R2, a Vietnamese Ginseng Saponin(Pharmacology)
- The Effects of Choto-san on the mRNA Expression of Alzheimer's Disease Related Factors in the Permanent Ischemic Rat Brain(Pharmacology)
- 脳虚血誘発のマウス空間認知障害に対する釣藤散の効果 (第15回天然薬物の開発と応用シンポジウム講演要旨集) -- (一般講演)
- Expression Changes of the mRNA of Alzheimer's Disease Related Factors in the Permanent Ischemic Rat Brain(Pharmacology)
- DNA array analysis of gene expression changes by Choto-san in the ischemic rat brain
- Evaluation of the Nitric Oxide Radical Scavenging Activity of Manganese Complexes of Curcumin and Its Derivative(Pharmacology)
- Cytoprotective and Cytotoxic Effects of Curcumin : Dual Action on H_2O_2-Induced Oxidative Cell Damage in NG108-15 Cells
- Protective effect of Choto-san and its related constituents on hydrogen peroxide-induced cell damage in NG108-15 cells
- Ameliorative Effects of Paeoniflorin, a Major Constituent of Peony Root, on Adenosine A_1 Receptor-Mediated Impairment of Passive Avoidance Performance and Long-Term Potentiation in the Hippocampus
- Paeoniflorin, a Major Constituent of Peony Root, Reverses Muscarinic M_1-Receptor Antagonist-Induced Suppression of Long-Term Potentiation in the Rat Hippocampal Slice
- Diazepam binding inhibitor (DBI) gene expression in the brains of socially isolated and group-housed mice
- GTS-21, a Nicotinic Agonist, Attenuates Multiple Infarctions and Cognitive Deficit Caused by Permanent Occlusion of Bilateral Common Carotid Arteries in Rats
- Chronic Cerebral Hypoperfusion-Induced Neuropathological Changes in Rats
- Tacrine Improves Working Memory Deficit Caused by Permanent Occlusion of Bilateral Common Carotid Arteries in Rats
- Effect of Pilocarpine on Striatal Acetylcholine Release in Dopamine-Depleted Rats
- In Vitro Antioxidant Activity of Vietnamese Ginseng Saponin and Its Components
- The Possible Involvement of GABA_A Systems in the Antinarcotic Effect of Majonoside-R2, a Major Constituent of Vietnamese Ginseng, in Mice
- P-64 Type II コラーゲン誘導性関節炎に対する「補中益気湯」の有効性と免疫調節作用の検討
- P-19 長期隔離飼育マウスのペントバルビタール誘発睡眠と闘争行動に対する四物湯及びその構成生薬の作用
- 慢性脳循環障害モデルとしての両側総頸動脈永久結紮ラットの有用性
- The mRNA Expression of Serotonin 2C Subtype Receptors Uncoupled With Inositol Hydrolysis in NG108-15 Cells
- 29G-03 抗コリン薬 scopolamine によるラット海馬長期増強現象の抑制とそれに対する芍薬成分 paeoniflorin の効果
- P-41 マウス肝及び脳ホモジェネートの脂質過酸化反応に対するベトナム人参サポニン画分及びその成分の影響
- 心理的ストレス負荷マウスにおける脳内脂質過酸化反応 : 一酸化窒素の関与及びGABA_A-ベンゾジアゼピン受容体系による修飾
- P-20 白血球及びマクロファージの貪食活性に及ぼすベトナム人参の影響
- P-18 慢性脳虚血ラットの学習行動障害に対する四物湯の影響
- II-A-9 ラットのスコポラミン誘発性空間認知障害に対する芍薬中のペオニフロリン関連成分の作用
- Antinociceptive and Antipyretic Effects of Alkaloids Extracted from the Stem Bark of Hunteria zeylanica
- P-8 芍薬成分 paeoniflorin の中枢作用に関する実験薬理学的研究
- Facilitatory and Inhibitory Effects of Harmaline on the Tryptophan- Induced 5-Hydroxytryptamine Syndrome and Body Temperature Changes in Pargyline-Pretreated Rats
- II-A-7 芍薬配糖体分画のスコポラミン誘発性空間認知障害に対する改善作用
- P-7 芍薬成分 paeoniflorin の記憶学習障害に対する改善作用
- I-A-19 前脳基底核破壊ラットの放射状迷路学習障害に対する芍薬成分 paeoniflorin の改善効果
- I-A-18 タイ民族薬 Randia siamensis Craib エキスの中枢作用
- P-10 総頚動脈永久結紮ラットの空間認知障害に対する Tetramethylpyrazine の改善作用
- A Comparative Study on the Effects of Nicotine and GTS : 21, a New Nicotinic Agonist, on the Locomotor Activity and Brain Monoamine Level
- Protective Effect of GTS-21, a Novel Nicotinic Receptor Agonist, on Delayed Neuronal Death Induced by Ischemia in Gerbils
- GTS-21, a Nicotinic Agonist, Protects against Neocortical Neuronal Cell Loss Induced by the Nucleus Basalis Magnocellularis Lesion in Rats
- 生薬の薬理学的評価:各種の学習行動障害モデルラットに対する四物湯及び構成生薬の作用 (〔第47回日本東洋医学会総会〕学会シンポジウム) -- (生薬資源の生産と品質管理)
- Paeoniflorin ameliorates acquisition impairment of a simple operant discrimination performance caused by unilateral nucleus basalis magnocellularis lesion in rats
- Neuropharmacological Actions of Pluchea indica LESS Root Extract in Socially Isolated Mice
- Antinociceptive Effects of Randia siamensis Extract and Its Constituent, Pseudoginsenoside-RP1 in Experimental Animals
- Serotonin 2C Receptor (5-HT2CR) mRNA Editing-Induced Down-Regulation of 5-HT2CR Function in Xenopus Oocytes : the Significance of Site C Editing
- 漢方方剤の中枢薬理作用の研究
- 5. ストレスと漢方方剤の実験薬理 (現代社会のストレスと漢方の役割)
- P-50 補中益気湯によるセロトニン 2C mRNA 発現促進作用
- 抗うつ薬連投によるセロトニン2C受容体mRNA発現