Cytoprotective and Cytotoxic Effects of Curcumin : Dual Action on H_2O_2-Induced Oxidative Cell Damage in NG108-15 Cells
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概要
- 論文の詳細を見る
The ability of curcumin, a natural antioxidant isolated from Curcuma longa, to inhibit hydrogen peroxide (H_2O_2)-induced cell damage in NG108-15 cells was examined. When added simultaneously with 500μM H_2O_2, curcumin (25-10μM) effectively protected cells from oxidative damage. However, when the cells were pretreated with curcumin (25-100μM) for 1.5 h before H_2O_2 exposure, curcumin was unable to inhibit H_2O_2-induced cell damage. Instead, it caused a significant concentration-dependent decrease in cell viability after H_2O_2 exposure. This dual action of curcumin suggests that pretreatment with curcumin by itself did not have any significant effect on the viability of the NG108-15 cells, but it sensitized them to oxidative damage induced by H_2O_2 under our experimental conditions. It appears that these events may not relate to the antioxidant and free radical scavenging activities of curcumin.
- 社団法人日本薬学会の論文
- 2003-05-01
著者
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Tohda Michihisa
和漢医薬学総合研究所 複合薬物薬理学分野
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Tohda Michihisa
富山医科薬科大学和漢薬研究所
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Tohda Michihisa
タイ
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Tohda Michihisa
Department Of Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical Universit
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渡辺 裕司
International Research Center For Traditional Medicine Toyama Prefecture International Health Comple
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Watanabe Hiroshi
Department of Cardiology, Niigata City General Hospital
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MAHAKUNAKORN Pramote
Department of Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical Univers
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MURAKAMI Yukihisa
Department of Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical Univers
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MATSUMOTO Kinzo
Department of Pharmacology, Institute of Natural Medicine, Toyama Medical and Pharmaceutical Univers
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Murakami Yukihisa
富山大学和漢医薬学総合研究所 複合薬物薬理学
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Mukarami Yukihisa
Institute Of Natural Medicine Toyama Medical And Pharmaceutical University
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Murakami Yukihisa
Division Of Medicinal Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical U
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Murakami Yukihisa
Research Institute For Wakan-yaku (traditional Sino-japanese Medicines)
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Murakami Yukihisa
Department Of Pharmacology Institute Of Natural Medicine:21st Century Coe Program Toyama Medical And
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Vajaragupta Opa
Department Of Pharmaceutical Chemistry Faculty Of Pharmacy Mahidol University
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Murakami Yuko
Department Of Bioactive Molecules National Institute Of Infectious Diseases
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Tohda Michihisa
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Hokkaido University
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Matsumoto Kinzo
Div. Of Medicinal Pharmacology Inst. Of Natural Medicine Univ. Of Toyama
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Matsumoto Kinzo
Division Of Medicinal Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical U
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Matsumoto Kinzo
Department Of Pharmacology Institute Of Natural Medicine:21st Century Coe Program Toyama Medical And
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Matsumoto K
Div. Of Medicinal Pharmacology Inst. Of Natural Medicine Univ. Of Toyama
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Mahakunakorn Pramote
Division Of Medicinal Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical U
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Matsumoto Kinzo
富山大学和漢医薬学総合研究所 複合薬物薬理学
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Murakami Y
Department Of Bioactive Molecules National Institute Of Infectious Diseases
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Murakami Y
Toho Univ. Chiba Jpn
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渡邉 裕司
富山医科薬科大学生物試験部門
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Watanabe Hiroshi
Department Of Applied Chemistry And Bioengineering Graduate School Of Engineering Osaka City Univers
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