Influence of Aging on Rolipram-Sensitive Phosphodiesterase Activity and [^3H] Rolipram Binding in the Rat Brain
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概要
- 論文の詳細を見る
To clarify the quantitative and qualitative changes in type IV phosphodiesterase (PDE IV) with aging, phosphodiesterase (PDE) activity and [^3H] rolipram binding in the cytosolic fraction from the brains of young and aged rats were examined. In all areas of the aged (100-week-old) rat brain except for hippocampus, the PDE activity was decreased by about half that in the young (10-week-old) animals. However, inhibition % by 100μM rolipram and by 100μM isobutylmethylxanthine (IBMX) was not significantly different between the aged and young rats. On the other hand, [^3H] rolipram binding and rolipram-sensitive PDE activity did not change with aging in the hippocampus, although both were decreased in other brain regions. These results suggest that PDE IV does not decrease with aging and maintains its cAMP degrading activity in the hippocampus. It may be involved in the dysfunction of the hippocampus with aging.
- 公益社団法人日本薬学会の論文
- 1996-02-15
著者
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Tohda Michihisa
富山大学和漢医薬学総合研究所
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Tohda Michihisa
Department Of Pharmacology Institute Of Natural Medicine Toyama Medical And Pharmaceutical Universit
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MURAYAMA Toshihiko
Departmen of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University
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NOMURA Yasuyuki
Departmen of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University
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Tohda M
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Hokkaido University:(present Address)d
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Tohda Michihisa
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Hokkaido University
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NOGIRI Shinsuke
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hokkaido University
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Nogiri Shinsuke
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Hokkaido University
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Nomura Yasuyuki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Hokkaido University
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MURAYAMA Toshihiko
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Hokkaido University
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