HIGH POTASSIUM-INDUCED, CALCIUM-DEPENDENT MONOAMINE RELEASE FROM BRAIN SLICES OF THE NEWBORN RAT
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概要
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To determine the functional significance of monoamines taken up into the newborn rat brain, a high K<SUP>+</SUP>-induced, Ca<SUP>2+</SUP>-dependent release of noradrenaline (NA), dopamine (DA) or serotonin (5-HT) from brain slices of the newborn rat was investigated and compared with that of the adult animal. Depolarization by increasing the potassium concentration in the medium induced the release of L-[<SUP>3</SUP>H]NA, [<SUP>3</SUP>H]DA or [<SUP>3</SUP>H]5-HT from brain slices prelabelled with the radioactive monoamines in the 2-day or 3-day-old rat as well as in the adult. The release of three [<SUP>3</SUP>H]amines was markedly inhibited by perfusing with Ca<SUP>2+</SUP> free medium in the presence of EGTA (2.0 mM) at both newborn and adult stages, although the inhibitory potency of Ca<SUP>2+</SUP> deficiency in the newborn preparation was lower than in the adult. The degree of the release against [<SUP>3</SUP>H]amines initially taken up in the newborn was of the same order of magnitude as those in the adult. It is suggested that NA, DA and 5-HT are stored in a functionally releasable pool of the nerve terminals of the central monoamine neurons in the rat and that these compounds act as neurotransmitters at birth and at the adult stage.
- 社団法人 日本薬理学会の論文
著者
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NOMURA Yasuyuki
Departmen of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University
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Segawa Tomio
Department Of Pharmacology Institute Of Pharmaceutical Sciences Hiroshima University School Of Medic
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YOTSUMOTO Ikuko
Department of Pharmacology, Institute of Pharmaceutical Sciences, Hiroshima University School of Med
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YOTSUMOTO Ikuko
Department of Pharmacology, Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine
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