Chronic effects of imipramine and lithium on 5-HT receptor subtypes in rat frontal cortex, hippocampus and choroid plexus: Quantitative receptor autoradiographic analysis.
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概要
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The effects of chronic treatment with imipramine or lithium on serotonin (5-HT) receptor subtypes were analyzed in the frontal cortex, hippocampus and choroid plexus of rat brain by quantitative receptor autoradiographic procedures, using radioligands [<SUP>3</SUP>H]-5-HT, [<SUP>3</SUP>H]-8-hydroxy-2-(di-n-propylamino)tetralin ([<SUP>3</SUP>H]-8-OH-DPAT), [<SUP>125</SUP>I]-iodocyanopindolol ([<SUP>125</SUP>I]-CYP), [<SUP>3</SUP>H]-mesulergine and [<SUP>125</SUP>I]-7-amino-8-iodo-ketanserin ([<SUP>125</SUP>I]-ketanserin) or [<SUP>3</SUP>H]-spiperone. Chronic i.p. administration of imipramine (20 mg/kg/day for 21 days) decreased the densities of 5-HT<SUB>1</SUB>, 5-HT<SUB>1A</SUB>, 5-HT<SUB>1C</SUB>, and 5-HT<SUB>2</SUB> sites in the frontal cortex, hippocampus and choroid plexus. Lithium (2 mEq/kg/day for 21 days) also decreased the densities of 5-HT<SUB>1</SUB>, 5-HT<SUB>1C</SUB>, and 5-HT<SUB>2</SUB> sites in the frontal cortex, and the densities of those including 5-HT<SUB>1A</SUB> sites in the hippocampus and choroid plexus. Imipramine and lithium very markedly decreased the density of 5-HT<SUB>1C</SUB>, sites in the choroid plexus. We propose that methods employing quantitative receptor autoradiographic analysis can be used to characterize and understand the local effects of these drugs on 5-HT receptor subtypes.
- 公益社団法人 日本薬理学会の論文
著者
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Segawa Tomio
Department Of Pharmacology Institute Of Pharmaceutical Sciences Hiroshima University School Of Medic
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MIZUTA Tadashi
Department of Pharmacology, Institute of Pharmaceutical Sciences, Hiroshima University School of Med
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MIZUTA Tadashi
Department of Pharmacology, Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine
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