INFLUENCES OF VERAPAMIL, X-537A, A-23187 AND ADENOSINE 3, 5-CYCLIC MONOPHOSPHATE ON RELEASE OF 5-HYDROXYTRYPTAMINE FROM RAT BRAIN SLICES
スポンサーリンク
概要
- 論文の詳細を見る
Influences of verapamil, X-537A, A-23187 and cyclic-AMP on the release of [<SUP>3</SUP>H]-5-HT taken up into rat brain slices, were examined. Incubation with 40 mm KCl induced tritium release which was dependent on the presence of Ca<SUP>2+</SUP>. Verapamil, which blocks Ca<SUP>2+</SUP> influx in excitable tissues, decreased potassium-induced release of 5-HT. Tritium release induced by ionophore X-537A was not dependent on extracellular Ca<SUP>2+</SUP> while that induced by A-23187 required Ca<SUP>2+</SUP>. Cyclic-AMP, dibutyryl cyclic-AMP and theophylline did not significantly stimulate 5-HT release either in the presence or absence of Ca<SUP>2+</SUP>.
- 社団法人 日本薬理学会の論文
著者
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Segawa Tomio
Department Of Pharmacology Institute Of Pharmaceutical Sciences Hiroshima University School Of Medic
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Murakami Hiroko
Department Of Clinical Pharmacy Faculty Of Pharmacy Meijo University
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KAJI Eiko
Department of Pharmacology, Institute of Pharmaceutical Sciences, Hiroshima University, School of Me
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KAJI Eiko
Department of Pharmacology, Institute of Pharmaceutical Sciences, Hiroshima University, School of Medicine
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MURAKAMI Hiroko
Department of Pharmacology, Institute of Pharmaceutical Sciences, Hiroshima University, School of Medicine
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