Clonidine reduces substance P binding in rat spinal cord membrane preparation.
スポンサーリンク
概要
- 論文の詳細を見る
The effects of clonidine on substance P (SP) binding was investigated using rat brain and spinal cord membrane preparations preincubated with various concentrations of clonidine. [<SUP>3</SUP>H]SP specific binding in the spinal cord was significantly decreased with 10-<SUP>4</SUP>M clonidine, but no effect on binding was seen in the brain. Scatchard analysis of SP binding indicated that Bmax was significantly depressed without changing the affinity. The mechanism of clonidine-induced analgesia includes a spinal neural component and action on the SP receptors.
- 公益社団法人 日本薬理学会の論文
著者
-
Nakata Yoshihiro
Department Of Biophysics Gunma University
-
Segawa Tomio
Department Of Pharmacology Institute Of Pharmaceutical Sciences Hiroshima University School Of Medic
-
Hama Aldric
Department of Pharmacology, Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine
関連論文
- Noradrenaline Induces Clock Gene Per1 mRNA Expression in C6 Glioma Cells Through β2-Adrenergic Receptor Coupled With Protein Kinase A – cAMP Response Element Binding Protein (PKA–CREB) and Src-Tyrosine Kinase – Glycogen Synthase Kinase-3β (Src–GSK-3β)
- Involvement of Voltage-Gated Sodium Channel Na_v1.8 in the Regulation of the Release and Synthesis of Substance P in Adult Mouse Dorsal Root Ganglion Neurons
- The Release of Substance P From Cultured Dorsal Root Ganglion Neurons Requires the Non-neuronal Cells Around These Neurons
- Possible Involvement of Long Chain Fatty Acids in the Spores of Ganoderma lucidum (Reishi Houshi) to Its Anti-tumor Activity(Pharmacology)
- Possible Involvement of P2X_7 Receptor Activation in Microglial Neuroprotection against Focal Cerebral Ischemia in Rats(Pharmacology)
- CB_1 Cannabinoid Receptor Stimulation Modulates Transient Receptor Potential Vanilloid Receptor 1 Activities in Calcium Influx and Substance P Release in Cultured Rat Dorsal Root Ganglion Cells
- APOMORPHINE- AND HALOPERIDOL-INDUCED CHANGE IN 3,4-DIHYDROXYPHENYLACETIC ACID CONTENT IN THE MESOLIMBIC-STRIATUM OF THE DEVELOPING RAT
- Modulation of the Substance P Release From Cultured Rat Primary Afferent Neurons by Zinc Ions
- Spinal Cord Shift on Magnetic Resonance Imaging at 24 Hours After Cervical Laminoplasty
- 5-HT-Induced, 5-HT_3 Receptor-Mediated, and Ruthenium Red- and Capsaicin-Sensitive Positive Chronotropic Effects in the Isolated Guinea Pig Atrium
- INTERACTIONS OF β-ADRENOCEPTOR BLOCKING AGENTS WITH SEROTONIN RECEPTOR SUBTYPES-SPECIAL REFERENCE TO THEIR PROPHYLACTIC EFFECT ON MIGRAINE
- Inhibitory Effect of EGTA on Serotonin Transport into Rabbit Blood Platelets: Possible Involvement of the Glycoprotein IIb/IIIa Complex
- Strategy for Modulation of Central Dopamine Transmission Based on the Partial Agonist Concept in Schizophrenia Therapy
- Anti-allergic Substances Contained in the Pollen of Cryptomeria japonica Possess Diverse Effects on the Degranulation of RBL-2H3 Cellse
- A Molecular Modeling Software System : The Molecular Model Handling System for Microcomputer
- EFFECTS OF 6-HYDROXYDOPA AND 5, 6-DIHYDROXYTRYPTOPHAN TREATMENT ON SPONTANEOUS MOTOR ACTIVITY AND BRAIN MONOAMINES IN MICE
- Dynamic Analysis Method for Electromagnetic Artificial Muscle Actuator under PID Control
- INFLUENCES OF VERAPAMIL, X-537A, A-23187 AND ADENOSINE 3, 5-CYCLIC MONOPHOSPHATE ON RELEASE OF 5-HYDROXYTRYPTAMINE FROM RAT BRAIN SLICES
- EFFECT OF APOMORPHINE ON MORPHINE-INDUCED DECREASE IN LOCOMOTOR ACTIVITY AND INCREASE IN DOPAMINE TURNOVER IN RATS
- A COMPARISON OF THE INHIBITORY EFFECTS OF CERTAIN ANTIPARKINSONIAN AGENTS ON DOPAMINE ACCUMULATION INTO THE RAT STRIATUM
- EFFECT OF COLD TREATMENT AND SOME DRUGS ON THE 5-HYDROXYTRYPTAMINE UPTAKE BY RABBIT BLOOD PLATELETS AND THEIR ULTRASTRUCTURE
- EFFECT OF CONCANAVALIN A ON 3H-5-HYDROXYTRYPTAMINE UPTAKE IN RABBIT BLOOD PLATELETS: INTERACTION WITH ADENYLATE CYCLASE ACTIVITY
- INFLUENCE OF THYROTROPIN-RELEASING HORMONE ON GENERAL BEHAVIOR AND STRIATAL [^3H] SPIPERONE BINDING IN DEVELOPING RATS
- INVOLVEMENT OF CENTRAL NORADRENERGIC SYSTEM IN THYROTROPIN-RELEASING HORMONE-INDUCED BEHAVIORAL EXCITEMENT IN 6-OHDOPA-TREATED, INFANT RATS
- DEVELOPMENT OF REGIONAL ACTIVITIES OF 2', 3'-CYCLIC NUCLEOTIDE 3'-PHOSPHOHYDROLASE AND CARBONIC ANHYDRASE IN THE RAT BRAIN : INFLUENCE OF 6-HYDROXYDOPA
- 6-HYDRXYDOPA-INDUCED STIMULATION OF ORNITHINE DECARBOXYLASE ACTIVITY IN THE DEVELOPING RAT BRAIN
- THE EFFECT OF PIPERIDINE AND PIPECOLIC ACID ON HIGH POTASSIUM-INDUCED RELEASE OF NORADRENALINE, SEROTONIN AND GABA FROM RAT BRAIN SLICES
- INFLUENCE OF PIPERIDINE AND PIPECOLIC ACID ON THE UPTAKE OF MONOAMINES, GABA AND GLYCINE INTO P_2 FRACTIONS OF THE RAT BRAIN AND THE SPINAL CORD
- SUBCELLULAR LOCALIZATION OF DOPAMINE IN THE RAT STRIATUM
- MECHANISM FOR THE INCREASE OF BRAIN 5-HYDROXY-TRYPTAMINE AND 5-HYDROXYINDOLEACETIC ACID FOLLOWING Δ9-TETRAHYDROCANNABINOL ADMINISTRATION TO RATS
- SOLUBILIZATION AND CHARACTERIZATION OF SUBSTANCE P BINDING PROTEIN FROM BOVINE BRAIN STEM
- HIGH POTASSIUM-INDUCED, CALCIUM-DEPENDENT MONOAMINE RELEASE FROM BRAIN SLICES OF THE NEWBORN RAT
- STRIATAL DOPAMINE CONTENT REDUCED IN DEVELOPING RATS TREATED WITH 6-HYDROXYDOPA
- REGIONAL CHANGES IN BRAIN CATECHOLAMINE CONTENT FOLLOWING ADMINISTRATION OF GUANETHIDINE TO NEONATAL RATS
- INFLUENCES OF SODIUM, OUABAIN AND TRICYCLIC ANTIDEPRESSANT DRUGS ON L-[3H]NOREPINEPHRINE UPTAKE INTO SYNAPTOSOMAL FRACTIONS OF DEVELOPING RAT BRAIN
- EFFECT OF IMIPRAMINE ON CENTRAL 5-HYDROXYTRYPTAMINE TURNOVER AND METABOLISM IN RATS
- FURTHER OBSERVATION ON THE LACK OF ACTIVE UPTAKE SYSTEM FOR SUBSTANCE P IN THE CENTRAL NERVOUS SYSTEM
- SUBSTANCE P IN THE CENTRAL NERVOUS SYSTEM OF RABBITS : UPTAKE SYSTEM DIFFERS FROM PUTATIVE TRANSMITTERS
- EFFECT OF ENKEPHALIN AND SUBSTANCE P ON SYMPATHETIC NERVE TRANSMISSION IN MOUSE VAS DEFERENS
- SIGNAL TRANSDUCTION FROM CATECHOLAMINE RECEPTORS TO ADENYLATE CYCLASE VIA GTP-BINDING PROTEINS IN ADULT AND OLD RAT BRAIN
- BRAIN SEROTONIN METABOLISM AND Δ9-TETRAHYDROCANNABINOL-INDUCED MURICIDE BEHAVIOR IN RATS
- Noradrenaline Induces Clock Gene Per1 mRNA Expression in C6 Glioma Cells Through β_2-Adrenergic Receptor Coupled With Protein Kinase A-cAMP Response Element Binding Protein (PKA-CREB) and Src-Tyrosine Kinase-Glycogen Synthase Kinase-3β (Src-GSK-3β)
- INFLUENCE OF NEONATAL 6-HYDROXYDOPA TREATMENT ON FUNCTIONAL DEVELOPMENT IN THE STRIATUM AND HEART
- THE ISOLATION OF HIGHLY 5-HYDROXYTRYPTAMINE CONCENTRATED FRACTION FROM RABBIT DUODENAL MUCOUS MEMBRANE HOMOGENATES
- ONTOGENESIS OF REARING AND STEREOTYPY RESPONSES TO APOMORPHINE IN THE RAT
- SYNTHETIC α-MELANOCYTE-STIMULATING HORMONE AND MOUSE BEHAVIOUR
- Developmental change in rearing response to atropine in rats treated with 6-hydroxydopa.
- Effect of reserpine, ouabain and p-chloromercuribenzoate on the release of 5-hydroxytryptamine from rat brain synaptosomes.
- Prostaglandin and norepinephrine metabolism: Effect of indomethacin on prostaglandin synthesis and norepinephrine turnover rate.
- BRAIN SEROTONIN METABOLISM IN LITHIUM TREATED RATS
- Volume Transmission of Substance P in Striatum Induced by Intraplantar Formalin Injection Attenuates Nociceptive Responses via Activation of the Neurokinin 1 Receptor
- Isolation of Substance P Binding Protein from Rat Brain.
- Effect of concanavalin A on 5'-nucleotidase activity of rabbit blood platelets.
- Effect of Concanavalin A on Intracellular Calcium Concentration in Single Blood Platelets.
- Clonidine reduces substance P binding in rat spinal cord membrane preparation.
- Active uptake system for substance P carboxy-terminal heptapeptide (5-11) into a fraction from rabbit enriched in glial cells.
- Effect of concanavalin A on serotonin transport into blood platelets: Possible involvement of protein kinase C.
- Selective blockade of dopamine D-1 receptor by SCH 23390 affects dopamine agonist binding to 3H-spiperone labeled D-2 receptors in rat striatum.
- Specific binding of (3H)WB 4101, (3H)clonidine and (3H)dihydroalprenolol in cerebral cortical membranes in developing, adult and old rats.
- UPTAKE AND STORAGE MECHANISM OF 5-HYDRO-XYTRYPTAMINE IN RABBIT BRAIN STEM AND EFFECT OF RESERPINE
- Chronic effects of imipramine and lithium on 5-HT receptor subtypes in rat frontal cortex, hippocampus and choroid plexus: Quantitative receptor autoradiographic analysis.
- Volume Transmission of Substance P in Striatum Induced by Intraplantar Formalin Injection Attenuates Nociceptive Responses via Activation of the Neurokinin 1 Receptor