BRAIN SEROTONIN METABOLISM IN LITHIUM TREATED RATS
スポンサーリンク
概要
- 論文の詳細を見る
Five days administration of Li (Li<SUB>2</SUB>CO<SUB>3</SUB> 2.5 mEq/kg, i.p. twice daily for 4 days, followed by one injection on the 5th day) to rats did not significantly alter brain serotonin (5-HT) levels. Animals appeared somewhat sedated but showed considerable exploratory and rearing behavior in new circumstances. Turnover rate of brain 5-HT as measured from the accumulation after inhibiting monoamine oxidase was decreased by repeated administration of Li. Furthermore, Li lessened the depletion rate of brain 5-HT by reserpine. These results suggest that certain of the effects of Li on manic states can be attributed to the reduced functional activity of brain 5-HT neurons.
- 公益社団法人 日本薬理学会の論文
著者
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Segawa Tomio
Department Of Pharmacology Institute Of Pharmaceutical Sciences Hiroshima University School Of Medic
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NAKANO Masumi
Department of Pharmacology, Institute of Pharmaceutical Sciences Hiroshima University School of Medicine
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SEGAWA Tomio
Department of Pharmacology, Institute of Pharmaceutical Sciences Hiroshima University School of Medicine
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