EFFECT OF IMIPRAMINE ON CENTRAL 5-HYDROXYTRYPTAMINE TURNOVER AND METABOLISM IN RATS
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概要
- 論文の詳細を見る
The levels of [<SUP>3</SUP>H]-5-HT and [<SUP>3</SUP>H]-5-HIAA in P<SUB>2</SUB>-fraction from rats treated with a single dose of imipramine were lower at 2, 5 and 10 min after intraventricular administration of [<SUP>3</SUP>H]-5-HT, compared with control animals, though these levels were statistically insignificant. Thereafter, however, the values became higher than in the controls. After long-term administration of imipramine, the levels of [<SUP>3</SUP>H]-5-HT and [<SUP>3</SUP>H]-5-HIAA in P<SUB>2</SUB>-fraction were, at any time after intraventricular administration of [<SUP>3</SUP>H]-5-HT, significantly lower than those in the fraction from controls. The endogenous contents of tryptophan and 5-HIAA were not altered either with a single dose or by long-term administration of imipramine, however, the content of endogenous 5-HT was decreased by long-term administration of imipramine. These results indicate that the rate of disappearance of 5-HT from presynaptic neurons was accerelated by long-term administration of imipramine.
- 社団法人 日本薬理学会の論文
著者
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Segawa Tomio
Department Of Pharmacology Institute Of Pharmaceutical Sciences Hiroshima University School Of Medic
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MIZUTA Tadashi
Department of Pharmacology, Institute of Pharmaceutical Sciences, Hiroshima University School of Med
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MIZUTA Tadashi
Department of Pharmacology, Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine
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