THE EFFECT OF PIPERIDINE AND PIPECOLIC ACID ON HIGH POTASSIUM-INDUCED RELEASE OF NORADRENALINE, SEROTONIN AND GABA FROM RAT BRAIN SLICES
スポンサーリンク
概要
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The effect of piperidine and D, L-pipecolic acid on a Ca^<2+> -dependent release of L-[^3H] noradrenaline (L-[^3H] NA), [^3H] 5-hydroxytryptamine ([^3H] 5-HT) and [^<14>C] GABA from the rat brain slices preloaded of radioactive amines and acid were investigated. Piperidine 10^<-4> M did not affect high K^+ -induced release of L-[^3H] NA, [^3H] 5-HT and [^<14>C] GABA as well as spontaneous release of these amines and acid. On the other hand, D, L-pipecolic acid (10^<-4> M) significantly increased high K^+ -induced release of [^<14>C] GABA but not of L-[^3H] NA or [^3H] 5-HT. These results suggest that the hypnogenic and tranquilizing effect of piperidine is due to other mechanism than influence on NA, 5-HT and GABA at nerve terminals of central NA, 5-HT and GABA neurons, and that pipecolic acid possibly could potentiate the synaptic transmission of GABA in the central nervous system.
- 公益社団法人日本薬学会の論文
著者
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OKUMA Yasunobu
Departmen of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University
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NOMURA Yasuyuki
Departmen of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University
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Okuma Yasunobu
Department Of Pharmacology Institute Of Pharmaceutical Sciences Hiroshima University School Of Medic
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Segawa Tomio
Department Of Pharmacology Institute Of Pharmaceutical Sciences Hiroshima University School Of Medic
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Nomura Yasuyuki
Department Of Pharmacology Institute Of Pharmaceutical Sciences Hiroshima University School Of Medic
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Segawa Tomio
Department Of Pharmacology Institute Of Pharmaceutical Sciences Hiroshima University School Of Medic
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