Effects of Bifemelane Hydrochloride, a Brain Function Improver, on Muscarinic Receptors in the CNS of Senescence-Accelerated Mouse.
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概要
- 論文の詳細を見る
Senescence-accelerated mouse (SAM-P/8) is known as a murine model of aging and memory dysfunction, compared with control mouse (SAM-R/1). In the hippocampus of 9-month-old SAM-P/8, the B<SUB>max</SUB> of [<SUP>3</SUP>H]QNB binding was decreased compared with that of SAM-R/1 at the same age. Single and repeated administrations of bifemelane to SAM-P/8 induced an increase in the B<SUB>max</SUB> of [<SUP>3</SUP>H]QNB binding in the hippocampus. From these results, bifemelane seems to exert pharmacological effects through possible activation of the cholinergic system in the hippocampus of SAM.
- 公益社団法人 日本薬理学会の論文
著者
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NOMURA Yasuyuki
Departmen of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University
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Ohnuki Toshio
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Hokkaido University
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Kitamura Yoshihisa
Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Japan
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