Enhancement of (3H)clonidine binding to rat cerebral synaptic membranes by treatment with arachidonic acid, prostaglandin (PG) D2, PGE2 and PGF2.ALPHA..

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概要

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• Pretreatment of cerebral synaptic membranes with arachidonic acid (10 nM—1 μM) at 37°C for 40 min caused a significant increase in [<SUP>3</SUP>H]clonidine binding but pretreatment at 4°C did not. Scatchard analysis showed that 100 nM arachidonic acid pretreatment resulted in a significant elevation of the B<SUB>max</SUB> value of the low affinity site. PGD<SUB>2</SUB>, PGE<SUB>2</SUB> and PGF<SUB>2α</SUB> (10-100 μM) pretreatment also enhanced binding. These polyunsaturated fatty acids could be involved in regulation of the α<SUB>2</SUB>-adrenoceptor binding in rat cerebral cortical membranes.

• 公益社団法人 日本薬理学会の論文

著者

• NOMURA Yasuyuki

  Departmen of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University

• Kitamura Yoshihisa

  Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Japan

• NOMURA Yasuyuki

  Department of Pharmacology, Research Institute for Wakan-yaku (Oriental Medicines), Toyama Medical and Pharmaceutical University

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