Possible Involvement of Small Oligomers of Amyloid-β Peptides in 15-Deoxy-△^<12,14> Prostaglandin J_2-Sensitive Microglial Activation
スポンサーリンク
概要
- 論文の詳細を見る
In Alzheimer’s disease, fibrillar amyloid-β (Aβ) peptides form senile plaques associated with microglia. However, the relationship between Aβ peptides and microglia is not fully understood. In this study, the incubation of Aβ1-40 (Aβ40) produced small oligomers, while incubation with Aβ1-42 (Aβ42) caused large molecular aggregates. Microglial production of nitrite, interleukin-6 and tumor necrosis factor-α was induced by Aβ40, but not Aβ42. This production was significantly reduced by 15-deoxy-Δ12,14 prostaglandin J2, and it was completely suppressed by β-sheet breaker peptide, Leu-Pro-Phe-Phe-Asp. These results suggest that small oligomers, rather than large molecular aggregates, mediate microglial activation induced by Aβ peptides.
- 社団法人 日本薬理学会の論文
- 2003-04-01
著者
-
Takata Kazuyuki
Faculty Of Pharmaceutical Sciences Hoshi University
-
Taniguchi Takashi
Department of Geophysics, Faculty of Science, Hokkaido University
-
Taniguchi T
Department Of Neurobiology Kyoto Pharmaceutical University
-
Takahashi Kazunori
京都薬科大学 病態生理学
-
Taniguchi Takashi
京都薬科大学 病態生理学
-
Shimohama Shun
Department of Neurology, Sapporo Medical University School of Medicine
-
KITAMURA Yoshihisa
Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University
-
Shimohama S
Kyoto Univ. Kyoto Jpn
-
Shimohama Shun
Department Of Neurology Faculty Of Medicine Kyoto University
-
Kondo Jun-ichi
Department Of Neurobiology Kyoto Pharmaceutical University
-
TAKATA Kazuyuki
Department of Neurobiology, Kyoto Pharmaceutical University
-
TSUCHIYA Daiju
Department of Neurobiology, Kyoto Pharmaceutical University
-
UMEKI Masaaki
Department of Neurobiology, Kyoto Pharmaceutical University
-
KAKIMURA Jun-ichi
Department of Neurobiology, Kyoto Pharmaceutical University
-
GEBICKE-HAERTER Peter
Department of Psychopharmacology, Central Institute of Mental Health
-
Umeki Masaaki
Department Of Neurobiology Kyoto Pharmaceutical University
-
Tsuchiya Daiju
Department Of Neurobiology 21st Century Coe Program Kyoto Pharmaceutical University
-
Takata Kazuyuki
Department Of Mechanical Engineering Aichi Institute Of Technology
-
Takeuchi Kosei
Kan Research Institute Inc. Kobe Mi R&d Center
-
Takenawa Tadaomi
Division Of Biochemistry Institute Of Medical Science University Of Tokyo
-
Kakimura Jun-ichi
Department Of Neurophysiology Graduate School Of Biomedical Sciences Hiroshima University
-
Kakimura Jun-ichi
Department Of Neurobiology Kyoto Pharmaceutical University
-
Kanai Yoshihito
Department Of Pharmaceutical Care And Health Sciences Okayama University Graduate School Of Medicine
-
Kitamura Yoshihisa
Department Of Neurobiology Kyoto Pharmaceutical University
-
Kitamura Yoshihisa
Department Of Pharmacology Research Institute For Wakan-yaku Toyama Medical And Pharmaceutical Unive
-
Gebicke-haerter Peter
Department Of Psychopharmacology Central Institute Of Mental Health
-
Kitamura Y
Department Of Neurobiology Kyoto Pharmaceutical University
-
Kitamura Y
Shimizu Pharmaceutical Co. Ltd. Shizuoka Jpn
-
Taira Takahiro
Graduate School Of Pharmaceutical Sciences Hokkaido University:crest Japan Science And Technology Co
-
Takano T
Dep. Of Neurobiology Kyoto Pharmaceutical Univ.
-
Taniguchi Takashi
Department Of Geophysics Faculty Of Science Hokkaido University
-
Taniguchi Takashi
Department Of Dermatology Faculty Of Medicine University Of Tokyo
-
Takata Kazuyuki
Department of Clinical and Translational Physiology, Kyoto Pharmaceutical University
-
TANIGUCHI Takashi
Department of Computational Science and Engineering, Nagoya University
-
Kitamura Yoshihisa
Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University, Japan
-
Taniguchi Takashi
Department of Biology, Kyoto Pharmaceutical University
-
KITAMURA Yoshihisa
Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Okayama University
関連論文
- Response of Serum Carboxylated and Undercarboxylated Osteocalcin to Risedronate Monotherapy and Combined Therapy with Vitamin K2 in Corticosteroid-Treated Patients: A Pilot Study
- Identification of a Novel Planarian G-Protein-Coupled Receptor That Responds to Serotonin in Xenopus laevis Oocytes
- Oxidative Neurodegeneration Is Prevented by UCP0045037, an Allosteric Modulator for the Reduced Form of DJ-1, a Wild-Type of Familial Parkinson's Disease-Linked PARK7
- DJ-1 binds to mitochondrial complex I and maintains its activity
- Chemical Compositions of Aerosol Particles and Snowfalls at Alta, Northern Norway
- Chemical Characteristics of Atmospheric Aerosol Particles on a High Mountain and an Urban Area in Sapporo, Japan
- Chemical Compositions of Atmospheric Aerosol Particles in Relation to the Wind Direction in Winter Season, Sapporo, Japan
- Chemical Compositions of Atmospheric Aerosol Particles in Relation to the Wind Direction at a High Mountain and Urban Area in Sapporo, Japan
- Oxidation of DJ-1-dependent cell transformation through direct binding of DJ-1 to PTEN
- Neuroprotective Effects of Quercetin and Rutin on Spatial Memory Impairment in an 8-Arm Radial Maze Task and Neuronal Death Induced by Repeated Cerebral Ischemia in Rats
- Disruption of Phospholipase Cδ4 Gene Modulates the Liver Regeneration in Cooperation with Nuclear Protein Kinase C
- Nicotinic Acetylcholine α4β2 Receptor Regulates the Motivational Effect of Intracranial Self Stimulation Behavior in the Runway Method
- Parkinsonian Rotenone Mouse Model: Reevaluation of Long-Term Administration of Rotenone in C57BL/6 Mice
- Chronic Treatment with Imipramine and Lithium Increases Cell Proliferation in the Hippocampus in Adrenocorticotropic Hormone-Treated Rats
- Anisotropy in Storage Modulus of Magnetic Gels Induced by Magnetization
- New design of N-isopropyl-p-[^I]iodoamphetamine (^I-IMP) lung imaging in the patient with lung cancer
- Protection Against Oxidative Stress-Induced Neurodegeneration by a Modulator for DJ-1, the Wild-Type of Familial Parkinson's Disease-Linked PARK7
- Protection Against Oxidative Stress-Induced Neurodegeneration by a Modulator for DJ-1, the Wild-Type of Familial Parkinson’s Disease-Linked PARK7
- Uniaxial Elongational Viscosity of PC/ A Small Amount of PTFE Blend
- Massive Epistaxis From a Thrombosed Intracavernous Internal Carotid Artery Aneurysm 2 Years After the Initial Diagnosis : Case Report
- Proteasome Inhibitors Protect Against Degeneration of Nigral Dopaminergic Neurons in Hemiparkinsonian Rats
- Pharmacological Characteristics of Rotational Behavior in Hemiparkinsonian Rats Transplanted With Mouse Embryonic Stem Cell-Derived Neurons
- Possible Involvement of Small Oligomers of Amyloid-β Peptides in 15-Deoxy-△^ Prostaglandin J_2-Sensitive Microglial Activation
- Studies on Somnolence in the Daytime Caused by Drugs Used for Neuropathic Pain
- The Parkinsonian Models : Invertebrates to Mammals
- Effects of Nicotinic Receptor Agonists on Beta-Amyloid Beta-Sheet Formation
- Inhibitory Effects of Antiparkinsonian Drugs and Caspase Inhibitors in a Parkinsonian Flatworm Model
- Neurotrophic Effect of Hepatic Growth Factor (HGF) on Reinnervation of Perivascular Calcitonin Gene-Related Peptide (CGRP)-Containing Nerves Following Phenol-Induced Nerve Injury in the Rat Mesenteric Artery
- Effect of Diazepam on the Runway Method Using Priming Stimulation of Intracranial Self Stimulation Behavior
- The 5-HT_ Receptor Full Agonist, 8-OH-DPAT Inhibits ACTH-Induced 5-HT_ Receptor Hyperfunction in Rats : Involvement of 5-HT_ Receptors in the DOI-Induced Wet-Dog Shakes in ACTH-Treated Rats(Pharmacology)
- Increased DOI-Induced Wet-Dog Shakes in Adrenocorticotropic Hormone-Treated Rats Are Not Affected by Chronic Imipramine Treatment : Possible Involvement of Enhanced 5-HT_-Receptor Expression in the Frontal Cortex
- Developmental expression of neural Wiskott-Aldrich syndrome protein (N-WASP) and WASP family verprolin-homologous protein (WAVE)-related proteins in postnatal rat cerebral cortex and hippocampus
- Morphological Change by Overexpression of D385A Dominant Negative Presenilin 1 in Human Neuroblastoma SH-SY5Y Cells
- DJ-1, a Target Protein for an Endocrine Disrupter, Participates in the Fertilization in Mice
- Possible Involvement of P2X_7 Receptor Activation in Microglial Neuroprotection against Focal Cerebral Ischemia in Rats(Pharmacology)
- Identification and distribution of tryptophan hydroxylase (TPH)-positive neurons in the planarian Dugesia japonica
- Distribution of DJ-1, Parkinson's Disease-Related Protein PARK7, and Its Alteration in 6-Hydroxydopamine-Treated Hemiparkinsonian Rat Brain
- Recovery of Focal Brain Ischemia-Induced Behavioral Dysfunction by Intracerebroventricular Injection of Microglia
- FUNCTIONAL ASSAY OF DOPAMINERGIC AND SEROTONINERGIC NEURONS IN PLANARIAN(Physiology,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
- Intracerebroventricular Injection of Microglia Protects Against Focal Brain Ischemia
- Possible Involvement of Both Endoplasmic Reticulum -and Mitochondria-Dependent Pathways in Thapsigargin-Induced Apoptosis in Human Neuroblastoma SH-SY5Y Cells
- Involvement of Wiskott-Albrich Syndrome Protein Family Verprolin- Homologous Protein (WAVEAa9 and Rac1 in the Phagocytosis of Amyloid-β(1-42) in Rat Microglia
- Apoptotic Cell Death in Neurons and Glial Cells : Implications for Alzheimer's Disease
- Possible Involvement of Rapamycin-Sensitive Pathway in Bcl-2 Expression in Human Neuroblastoma SH-SY5Y Cells
- Motivational Effect of Nomifensine in the Intracranial Self-Stimulation Behavior Using a Runway Method(Pharmacology)
- Selegilin Exerts Antidepressant-Like Effects During the Forced Swim Test in Adrenocorticotropic Hormone-Treated Rats
- Motivational Effects of Methamphetamine as Measured by the Runway Method Using Priming Stimulation of Intracranial Self-stimulation Behavior(Analytical Biochemistry)
- Effects of Imipramine and Bupropion on the Duration of Immobility of ACTH-Treated Rats in the Forced Swim Test : Involvement of the Expression of 5-HT_ Receptor mRNA(Pharmacology)
- Nuclear reorganization during dedifferentiation of differentiated cells(Joint Symposium of the Society of Chromosome Research and the Chromosome Colloquium : "Dynamics of genome and chromosomes-aspects from gene expression to evolution-",Abstracts of the
- Structural Analysis of Nuclear Reprogramming during Newt Dedifferentiation Process(From Model Laboratory Species to Model Wild Species; the Next Generation of Model Animals Derived from Japan, but Applicable Worldwide: Japanese Wood Mouse, Japanese Medaka
- Hypnotic and Sleep Quality-Enhancing Properties of Kavain in Sleep-Disturbed Rats
- CLATHRIN-DEPENDENT ENDOCYTOSIS REQUIRED FOR NEURONAL CELL SURVIVAL IN PLANARIAN(Developmental Biology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- STUDY OF GENES REQUIRED FOR BRAIN REGENERATION AND NEURONAL MAINTENANCE IN PLANARIAN(Developmental Biology,Abstracts of papers presented at the 74^ Annual Meeting of the Zoological Society of Japan)
- Antiparkinsonian Drugs and Their Neuroprotective Effects
- Protective Effect of Talipexole on MPTP-Treated Planarian, a Unique Parkinsonian Worm Model
- Hypersomnia Caused by Isolated Angiitis of the CNS
- Structure and Characterization of AAT-1 Isoforms(Biochemistry/Molecular Biology)
- Demonstration of Acidic Fibroblast Growth Factor (FGF-1) in Rat Adrenal Gland
- 5-Hydroxytryptamine-induced Ca^-independent cGMP formation is mediated by nitric oxide in a nitric oxide synthase-independent manner in NG108-15 cells
- Acute Hyperglycemia and Hyperinsulinemia Enhance Adrenergic Vasoconstriction and Decrease Calcitonin Gene-Related Peptide-Containing Nerve-Mediated Vasodilation in Pithed Rats
- Transient Oculomotor Palsy Correlated with Nerve Enhancement on MRI in Chronic Inflammatory Demyelinating Polyneuropathy
- Photoproduction of η Mesons from Protons at Incident Energies below 1 GeV
- Assessment of Protein Kinase C mRNA Levels in Alzheimer's Disease Brains
- Improvement of Mechanical Properties for Poly (L-lactic acid) Film through Drawing Process Optimization
- Fatigue Properties of TiNi Shape Memory Alloy
- Abundance of Low Molecular Weight Phosphotyrosine Protein Phosphatase in the Nerve-Ending Fraction in the Brain
- Neuroprotective effect of a new DJ-1-binding compound against neurodegeneration in Parkinson's disease and stroke model rats
- Inhibitory Effects of Talipexole and Pramipexole on MPTP-InducedDopamine Reduction in the Striatum of C57BL/6N Mice
- EFFECTS OF CDP-CHOLINE ON STRIATAL DOPAMINE LEVEL AND BEHAVIOR IN RATS
- ON THE SNOW CRYSTALS OF LOW TEMPERATURE TYPES
- Prostaglandin E_2 Has No Effect on Two Components of Tetrodotoxin-Resistant Na^+ Current in Mouse Dorsal Root Ganglion
- Use-Dependent Removal of the 4-Aminopyridine-Induced Block of the Transient K^+ Current in Rat Dorsal Root Ganglia
- Alterations of Phospholipase C Isozymes in Rat Cerebral Cortex through Hyperoxia
- Involvement of Dopaminergic Receptor Signaling in the Effects of Glutamatergic Receptor Antagonists on Conditioned Place Aversion Induced by Naloxone in Single-Dose Morphine-Treated Rats
- Characterization of the Inhibitory Effect of Vascular Endothelium on Agonist-Induced Vasoconstriction in Rat Mesenteric Resistance Arteries
- Nerve Growth Factor Suppresses Prostate Tumor Growth
- Age-Related Disappearance of the Inhibitory Effect of Vascular Endothelium on Agonist-Induced Vasoconstriction in Rat Mesenteric Vascular Beds
- WASP and WAVE family proteins : Friends or foes in cancer invasion?
- The Hydroxyl Radical Formation System in Polymorphonuclear Leukocytes
- Participation of Cytosolic Protein Phosphatase in Regulation of NADPH Oxidase in Polymorphonuclear Leukocytes
- Zinc-Ion-Dependent Acid Phosphatase Exhibits Magnesium-Ion-Dependent myo-Inositol-1-phosphatase Activity
- Characterization of High- and Low-Molecular Weight Zinc-Dependent Acid Phosphatases in Bovine Liver
- Effect of Pharmacist Management on Serum Hemoglobin Levels with Renal Anemia in Hemodialysis Outpatients
- Maps of Lakes' Thermal Regimes in Japan
- New Molecular Mechanisms for Cardiovascular Disease:Contribution of Endothelium-Derived Hyperpolarizing Factor in the Regulation of Vasoconstriction in Peripheral Resistance Arteries
- Clinical Outcome of Patients with SREDA (Subclinical Rhythmic EEG Discharge of Adults)
- Protection Against Dopaminergic Neurodegeneration in Parkinson’s Disease–Model Animals by a Modulator of the Oxidized Form of DJ-1, a Wild-type of Familial Parkinson’s Disease–Linked PARK7
- Nicotinic Receptor-Mediated Neuroprotection in Neurodegenerative Disease Models(Functional Changes Induced by Long-Term Stimulation of Nicotinic Acetylcholine Receptors)
- Measurements of the number concentration of aerosol particles in northern Norway (abstract)
- Detoxification of 6-Hydroxydopamine-Induced Dopaminergic Neurodegeneration by 5,5-Dimethyl-1-pyrroline N-Oxide, a Radical Trapper, in Hemiparkinsonian Rats
- Molecular Approaches to the Treatment, Prophylaxis, and Diagnosis of Alzheimer's Disease: Tangle Formation, Amyloid-β, and Microglia in Alzheimer's Disease
- Protection Against Dopaminergic Neurodegeneration in Parkinson's Disease-Model Animals by a Modulator of the Oxidized Form of DJ-1, a Wild-type of Familial Parkinson's Disease-Linked PARK7
- Pharmacological Characteristics of Rotational Behavior in Hemiparkinsonian Rats Transplanted With Mouse Embryonic Stem Cell-Derived Neurons
- Effect of Selective Serotonin Reuptake Inhibitors via 5-HT_ Receptors on L-DOPA-Induced Rotational Behavior in a Hemiparkinsonian Rat Model
- Detoxification of 6-Hydroxydopamine-Induced Dopaminergic Neurodegeneration by 5,5-Dimethyl-1-pyrroline N-Oxide, a Radical Trapper, in Hemiparkinsonian Rats
- Effect of Selective Serotonin Reuptake Inhibitors via 5-HT1A Receptors on L-DOPA-Induced Rotational Behavior in a Hemiparkinsonian Rat Model
- Thyrotoxic Myopathy Mimicking Myasthenic Syndrome Associated with Thymic Hyperplasia
- Prostaglandin E2 Has No Effect on Two Components of Tetrodotoxin-Resistant Na+ Current in Mouse Dorsal Root Ganglion
- Gluten Sensitivity in Japanese Patients with Adultonset Cerebellar Ataxia
- Reassessment of (3H)glutamate binding to human brain membrane preparations.